Advances in Traditional Medicine

  • 제2권1호
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  • Pages.47-51
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  • 2002
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  • 2662-4052(pISSN)
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  • 2662-4060(eISSN)
경희대학교 융합한의과학연구소 (Kyung Hee Oriental Medicine Research Center)
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Inhibitory effect of Se-Yeon-Eum on nicotine- and cigarette smoke extract induced cytotoxicity in human lung fibroblast

  • Jin Chong-Shik (Department of Oriental Pharmacy, College of Pharmacy, Wonkwang University) ;
  • Kim Mi-Sun (Department of Oriental Pharmacy, College of Pharmacy, Wonkwang University) ;
  • Lee Eun-Hee (Department of Oriental Pharmacy, College of Pharmacy, Wonkwang University) ;
  • Lee Joon-Ho (Department of Oriental Pharmacy, College of Pharmacy, Wonkwang University) ;
  • Lee Jong-Hyun (Department of Oriental Pharmacy, College of Pharmacy, Wonkwang University) ;
  • Moon Su-Jin (Department of Oriental Pharmacy, College of Pharmacy, Wonkwang University) ;
  • Lee Bo-Ra (Department of Oriental Pharmacy, College of Pharmacy, Wonkwang University) ;
  • Jung Kyung-Phil (Department of Oriental Pharmacy, College of Pharmacy, Wonkwang University) ;
  • Li Hong-Yuan (Department of Epidemiology, Public Health College, Harben Medical University)
  • 발행 : 2002.02.01
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초록

There are over 4,000 different chemicals in cigarette smoke, including nicotine and tar. These compounds influence on lung tissue directly or indirectly. In this study, we have examined whether an aqueous extract of Se-Yeon-Eum (SYE), composed of Oriental medicine that has been known to be effective to symptom by smoking, inhibits nicotine- or cigarette smoke extract (CSE)-induced cytotoxicity in human embryonic lung fibroblast, MRC-9. Assessment of cell viability using 3-(4,5-dimethythiazol-2-yl)-2,5-diphenyltetrazolium bromide colorimetric assay indicated that SYE inhibited not only nicotine-induced cytotoxicity but also CSE-induced cytotoxicity. These results suggest the possibility that the use of SYE may be useful for improvement of many symptoms by smoking.

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피인용 문헌

  1. Effect of Se-Yeon-Eum on nitric oxide and tumor necrosis factor-α production in C6 glial cells induced by recombinant interferon-γ and cigarette extract vol.17, pp.3, 2017, https://doi.org/10.1007/s13596-017-0261-2