The Korean Journal of Physiology and Pharmacology

The Korean Society of Pharmacology (대한약리학회)
권호 표지

Changes in Vestibular Nerve Activity Following Acute Hypotension in Rats

  • Park, Byung-Rim (Department of Physiology, Wonkwang University School of Medicine and Vestibulocochlear Research Center at Wonkwang University) ;
  • Kim, Min-Sun (Department of Physiology, Wonkwang University School of Medicine and Vestibulocochlear Research Center at Wonkwang University) ;
  • Yee, Gue-Hyun (Department of Physiology, Wonkwang University School of Medicine and Vestibulocochlear Research Center at Wonkwang University) ;
  • Moon, Myoung-Jin (Department of Physiology, Wonkwang University School of Medicine and Vestibulocochlear Research Center at Wonkwang University) ;
  • Kim, Jae-Hyo (Department of Physiology, Wonkwang University School of Medicine and Vestibulocochlear Research Center at Wonkwang University) ;
  • Jin, Yuan-Zhe (Department of Physiology, Wonkwang University School of Medicine and Vestibulocochlear Research Center at Wonkwang University) ;
  • Kim, Yo-Sik (Department of Neurology, Wonkwang University School of Medicine and Vestibulocochlear Research Center at Wonkwang University)
  • Published : 2003.04.21
Download PDF
⟨ Previous Next ⟩

Abstract

The basic mechanism for the excitation of the peripheral vestibular receptors following acute hypotension induced by sodium nitroprusside (SNP) or hemorrhage was investigated in anesthetized rats. Electrical activity of the afferent vestibular nerve was measured after pretreatment with kynurenic acid, an NMDA receptor antagonist. The activity of the vestibular nerve at rest following acute hypotension induced by SNP or simulating hemorrhage was a greater increase than in control animals. The gain of the vestibular nerve with sinusoidal rotation following acute hypotension increased significantly compared to control animals. The acute hypotension induced by SNP or hemorrhage did not change the activity of the afferent vestibular nerve after kynurenic acid injection. These results suggest that acute hypotension produced excitation of the vestibular hair cells via glutamate excitotoxicity in response to ischemia.

Keywords

References

  1. Andrews JC, Hoover LA, Lee RS, Honrubia V. Vertigo in the hyperviscosity syndrome. Otolaryngol Head Neck Surg 98: 144－149, 1988 https://doi.org/10.1177/019459988809800208
  2. Balaban CD, Porter JD. Neuroanatomic substrates for vestibuloautonomic interactions. J Vest Res 8: 7－16, 1998
  3. Biaggioni I, Costa F, Kaufman H. Vestibular influences on autonomic cardiovascular control in humans. J Vest Res 8: 35－41, 1998
  4. Bunemann L, Jensen KA, Riisager S, Thomsen LJ. Cerebral blood flow and metabolism during hypotension induced with sodium nitroprusside and metoprolol. Eur J Anaesthesiol 8: 197－201, 1991
  5. Choi DW, Rothman SM. The role of glutamate neurotoxicity in hypoxic -ischemic neuronal death. Annu Rev Neurosci 13: 171－182, 1990 https://doi.org/10.1146/annurev.ne.13.030190.001131
  6. Convertino VA. Interaction of semicircular canal stimulation with carotid baroreceptor reflex control of heart rate. J Vest Res 8: 43－49, 1998
  7. Doba N, Reis DJ. Role of the cerebellum and vestibular apparatus in regulation of orthostatic reflexes in the cat. Circ Res 34: 9－18, 1974 https://doi.org/10.1161/01.RES.34.1.9
  8. Goldberg JM, Fernandez C. Physiology of peripheral neurons innervating semicircular canals of the squirrel monkey. I. Resting discharge and response to constant angular accelerations. J Neurophysiol 34: 635－660, 1971
  9. Hakuba N, Koga K, Shudou M, Watanabe F, Mitani A, Gyo K. Hearing loss and glutamate efflux in the perilymph following transient hindbrain ischemia in gerbils. J Comp Neurol 418: 217－226, 2000 https://doi.org/10.1002/(SICI)1096-9861(20000306)418:2<217::AID-CNE7>3.0.CO;2-L
  10. Hamaguchi M, Ishibashi T, Katsumata N, Mitomi A, Imai S. Effect of sodium nitropursside (MR7S1) and nitroglycerin on the systemic, renal cerebral, and coronary circulation of dogs anesthetized with enflurane. Cardiovasc Drugs Ther 6: 611- 622, 1992 https://doi.org/10.1007/BF00052563
  11. Kennedy RS, Graybiel A, McDonough RC, Beckwith FD. Symptomatology under storm conditions in the North Atlantic in control subjects and in persons with bilateral labyrinth defects. Acta Otolaryngol 66: 533-540, 1968 https://doi.org/10.3109/00016486809126317
  12. Kikuchi S, Kaga K, Yamasoba T, Higo R, O'uchi T, Tokumaru A. Slow blood flow of the vetebrobasilar system in patients with dizziness and vertigo. Acta Otolaryngol 113: 257-260, 1993 https://doi.org/10.3109/00016489309135804
  13. Kim MS, Kim JH, Kry D, Choi MA, Choi DO, Cho BG, Jin YZ, Lee SH, Park BR. Effects of acute hypotension on expression of cFos-like protein in the vestibular nuclei of rats. Brain Res 962: 111-121, 2003 https://doi.org/10.1016/S0006-8993(02)03977-X
  14. Kolev OI, Tibbling L. Vestibular and cardiac reaction to open-sea exposure. J Vest Res 2: 153-157, 1992
  15. Manley GA, Gleich O, Leppelsack HJ, Oeckinghaus H. Activity patterns of cochlear ganglion neurones in the starling. J Comp Physiol 157: 161-181, 1985 https://doi.org/10.1007/BF01350025
  16. Normand D, Etard O, Denise P. Otolithic and tonic neck receptors control of limb blood flow in humans. J Appl Physiol 82: 1734－1738, 1997
  17. Park BR, Kim MS, Baik KH, Lee MY, Choi MA, Lee JH. Neuronal activity of the vestibular nuclei following acute hypotension in rats. Korean J Physiol Pharmacol 6: 199－205, 2002
  18. Park BR, Kim MS, Kim JH, Jin YZ. Effects of acute hypotension on neuronal activity in the medial vestibular nuclei of rats. Neuroreport 12: 3821－3824, 2001 https://doi.org/10.1097/00001756-200112040-00044
  19. Park BR, Kim MS, Lee MY, Kim YK, Choi SC, Nah YH. Effects of galvanic stimulation of the mastoid process on the gastric motility induced by caloric stimulation. Auris Nasus Larynx 26: 263－268, 1999 https://doi.org/10.1016/S0385-8146(99)00013-9
  20. Preckel MP, Degoute CS, Dubreuil C, Boulud B, Tassard AM, Banssillon V. Effect of buflomedil and naftidrofuryl on the human cochlear microcirculation measured by laser-Doppler. Rev Laryngol Otol Rhinol (Bord) 116: 69－72, 1995
  21. Puel JL, Pujol R, Tribillac F, Ladrech S, Eybalin M. Excitatory amino acid antagonists protect cochlear auditory neurons from excitotoxicity. J Comp Neurol 341: 241－256, 1994 https://doi.org/10.1002/cne.903410209
  22. Puel JL, Ruel J, Gervais d'Aldin C, Pujol R. Excitotoxicity and repair of cochlear synapses after noise-trauma induced hearing loss. Neuroreport 9: 2109－2114, 1998 https://doi.org/10.1097/00001756-199806220-00037
  23. Pujol R, Puel JL, Gervais d'Aldin C, Eybalin M. Pathophysiology of the glutamatergic synapses in the cochlea. Acta Otolaryngol 113: 330-334, 1993 https://doi.org/10.3109/00016489309135819
  24. Ueda T, Matsunaga T. The influence of unilateral vertebral artery occulusion on brainstem and inner ear blood flow in rat. Acta Otolaryngol 115: 742－746, 1995 https://doi.org/10.3109/00016489509139396
  25. Wilson VJ, Melvill Jones G. Mammalian vestibular physiology. New York, Plenum, 1979
  26. Yates BJ, Siniaia MS, Miller AD. Descending pathways necessary for vestibular influences on sympathetic and inspiratory outflow. Am J Physiol 268: R1381－1385, 1995
  27. Yates BJ. Vestibular influences on the sympathetic nervous system. Brain Res Rev 17: 51－59, 1992