Animal cells and systems

The Korean Society for Integrative Biology (한국통합생물학회)
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Expression of Endoplasmic Reticulum Chaperone ERp29 in the Injured Spinal Cord

  • Park, Soojung (Department of Anatomy, College of Medicine, Chungnam National University) ;
  • Hwang, Ho-Myung (Department of Anatomy, College of Medicine, Chungnam National University) ;
  • Lee, Young-Ho (Department of Anatomy, College of Medicine, Chungnam National University) ;
  • You, Kwan-Hee (Department of Biology, College of Natural Sciences, Chungnam National University) ;
  • Shin, Kee-Sun (Korea Research Institute of Bioscience and Biotechnology) ;
  • Kwon, O-Yu (Department of Anatomy, College of Medicine, Chungnam National University)
  • Published : 2003.09.01
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Abstract

Vascular endothelial growth factor (VEGF) is a potent regulator of normal and abnormal angiogenesis. Recent literature suggests that VEGF has several activities that may amplify acute inflammation reactions. Dysregulated VEGF expression has been implicated as a major contributor to the development of a number of common disease pathologies. One of common mutations in the 3'- untranslated region of the VEGF gene, a C\longrightarrowT exchange at nucleotide position 936, has been found to be significantly associated with VEGF expression levels in the plasma from a previous Austrian study. The frequency of this mutation could be important genetic information regarding tumor growth and angiogenesis related diseases. The aim of this study was to investigate the frequency distribution of this mutation in general Korean population. We examined the statistical data from 207 healthy Korean subjects. Observed numbers (%) of 936T were 28.5 (CT) and 3.9 (TT), respectively. The mutant allele frequency of 936T in Korean subjects was 0.18, which appeared somewhat higher than that in Austrian subjects.

Keywords

References

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