Animal cells and systems

The Korean Society for Integrative Biology (한국통합생물학회)
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Cellular Changes of Phenotype and Collagenase-1 Expression in Healing Corneal Stromal cells

  • Jung, Jae-Chang (Department of Biology, College of Natural Sciences, Kyungpook National University)
  • Published : 2003.09.01
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Abstract

Regulation of endoplasmic reticulum(ER) chaperone, ERp29, in traumatized rat spinal cord was investigated. Compared to the control, ERp29 expression was down-regulated at the lesion site 1 d after spinal cord injury. However, ERp29 expression gradually increased from 3 d after the injury and peaked remarkably after 7 d. Two ER chaperones (GRP94 and BiP) showed constantly strong expression levels 1 d after spinal cord injury while the expression levels of the other two (calnexin and PDI) were unchanged. In the case of ERp72, its expression level was increased 1 d after the injury and gradually decreased thereafter. This study suggests that ERp29 expression in the spinal cord after traumatic injury might be associated with the posttraumatic neural survival, playing a role as a molecular chaperone.

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References

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