Toxicological Research

Korean Society of Toxicology & Korea Environmental Mutagen Society (한국독성학회)
권호 표지

Mathematical and Statistical Characterization of LD50 Estimation

LD50 산출방법에 있어서 수리 · 통계학적 특성

  • 김세기 (성균관대학교 자연과학대학) ;
  • 김근종 (홍익대학교 상경대학) ;
  • 이병무 (성균관대학교 약학대학)
  • Published : 2004.09.01
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Abstract

Lethal dose 50% ($LD_{50}$) has been commonly used as a parameter for the estimation of acute toxicity not only in animal experiment, but also in human study. Several methods to estimate $LD_{50}$ had been introduced, but Spearman-Karber and Berens-Karber method have been widely used due to their relative convenience and accuracy. However, $LD_{50}$ values estimated from the two methods showed inconsistency and variation depending on the characteristics of mortality data. In this study, the two methods were comparatively investigated in terms of accuracy and stability for the estimation of $LD_{50}$.

Keywords

References

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