Journal of Physiology & Pathology in Korean Medicine (동의생리병리학회지)

The Physiological Society of Korean Medicine and The Society of Pathology in Korean Medicine (대한동의생리학회·한의병리학회)
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Effects of Extract of Radix Achyranthis Bidentatae on Cadmium Inhalation Toxicity in Rats

우슬 추출물이 카드뮴 흡입폭로된 흰쥐의 독성해독에 미치는 영향

  • Kim Hong Ki (Department of Oriental Medicine, Graduate School of Wonkwang University) ;
  • Jeung Jaeyeal (The Third Medicine, Professional Graduate School of Oriental Medicine, Wonkwang University) ;
  • Park Seung Jong (Department of Oriental Medicine, Graduate School of Wonkwang University) ;
  • Kang Sung Ho (The Third Medicine, Professional Graduate School of Oriental Medicine, Wonkwang University) ;
  • Song Young Sun (The Third Medicine, Professional Graduate School of Oriental Medicine, Wonkwang University) ;
  • Lee Ki-Nam (The Third Medicine, Professional Graduate School of Oriental Medicine, Wonkwang University)
  • 김홍기 (원광대학교 대학원 한의학과) ;
  • 정재열 (원광대학교 한의학전문대학원 제3의학과) ;
  • 박승정 (원광대학교 대학원 한의학과) ;
  • 강성호 (원광대학교 한의학전문대학원 제3의학과) ;
  • 송용선 (원광대학교 한의학전문대학원 제3의학과) ;
  • 이기남 (원광대학교 한의학전문대학원 제3의학과)
  • Published : 2004.04.01
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Abstract

To know the effects between Cd inhalation toxicity and extract of Radix Achyranthis Bidentatae, 4 rat groups were exposed to Cd aerosol in air using whole-body inhalation exposure for 6 hours/day, 5 days/week, and 4 weeks. Cd concentration in air was 1.03㎎/㎥ and mass median diameter(MMD) was 1.69㎛. 3 different dose intraperitoneal injections of extract of Radix Achyranthis Bidentatae to 3 inhalation exposure groups was done for 4 weeks and the results were as follows: The highest body weight gain for 4 weeks and food intake per day were from inhalation exposure group I and the highest lung and liver weight were also from inhalation exposure group I. The highest kidney weight was from inhalation exposure group III. The lowest Cd content in lung was 33.49㎍/g from inhalation exposure group I. The lowest Cd concentration in blood was 9.36㎍/㎗ from inhalation exposure control. Cd concentrations of 40.02㎍/g in liver and 69.18㎍/g in kidney were the lowest from inhalation exposure group I and III, respectively. The lowest Cd concentration in liver was 21.08㎍/g from inhalation exposure group III and The lowest Cd concentration in kidney was 15.78㎍/g from inhalation exposure group II. For weekly Cd concentration in urine, the value of the fourth week from inhalation exposure group III was the highest. For weekly Cd concentration in feces, the value of the first week from inhalation exposure group III was the highest. The highest metallothionein concentration in lung was 53.42 ㎍/g from inhalation exposure group III and the highest metallothionein concentration in liver was 188.18㎍/g from inhalation exposure group III. The highest metallothionein concentration in kidney was 143.92㎍/g from inhalation exposure group III. The highest Hct, Hb, and WBC values were from inhalation exposure group II and the highest RBC value was from inhalation exposure group III.

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