Journal of Physiology & Pathology in Korean Medicine (동의생리병리학회지)

The Physiological Society of Korean Medicine and The Society of Pathology in Korean Medicine (대한동의생리학회·한의병리학회)
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Vasodilation Effect of the Water Extract of Alcohol Steamed Rheum undulatum L. in Rat Thoracic Aorta

종대황의 주습 수치 방법에 따른 백서의 흉부대동맥 혈관이완에 미치는 영향

  • Kim Hyung Hwan (Vascular Medicine Research Unit, Cardiovascular Division, Brigham & Women's Hospital and Harvard Medical School) ;
  • Park Soo Yeon (Research institute of Physical education, Kyunghee University) ;
  • Ahn Duk Kyun (Jaseng research institute of biotechnology & bioscience) ;
  • Park Seong Kyu (College of Oriental Medicine, Kyunghee University)
  • 김형환 (하버드대학교 의과대학 여성병원 혈관의학연구실) ;
  • 박수연 (경희대학교 체육과학연구소) ;
  • 안덕균 (자생생명공학연구소) ;
  • 박성규 (경희대학교 한의과대학)
  • Published : 2004.02.01
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Abstract

We have examined the relaxative response to the water extract of Rheum undulatum L. (ERU) and water extract of alcohol steamed Rheum undulatum L. (SRU) with isolated thoracic aorta from sprague dawley (SD) rat. Rat thoracic aorta was investigated in vessel segments suspended for isometric tension recording by polygraph. Responses to ERU and SRU were investigated in vessels precontracted with 5-hydroxytryptamine(5-HT). We found that the thoracic aorta segments responded to ERU and SRU with a dose-dependent vasorelaxation : The thoracic aorta segments responded to ERU and SRU with a dose-dependent vasodilation. The amounts of emodin were 0.063%, 0.076% and 0.145% in ERU and SRU, respectable. The 5-HT induced contraction at 10-4M were inhibited by 85.2±4.76% and 84.0±2.91% after addition of the 0.1mg/mL water extract of ERU and SRU. The 5-HT induced contraction at 10/sup -3/M were inhibited by 100% after 10/sup -3/M emodin. In conclusion, vasodilation effect of the water extract of Rheum undulatum L. in rat thoracic aorta was not decreased according to the processing of alcohol steamed Rheum undulatum L.

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