Journal of Physiology & Pathology in Korean Medicine (동의생리병리학회지)

The Physiological Society of Korean Medicine and The Society of Pathology in Korean Medicine (대한동의생리학회·한의병리학회)
권호 표지

Effects of Phellodendron amurense Extract on the Alzheimer's Disease Model

황백(黃柏)이 Alzheimer's Disease 병태(病態) 모델에 미치는 영향

  • Kim, Young-Pyo (Department of Oriental Neuropsychiatry, College of Oriental Medicine, Daejeon University) ;
  • Jung, In-Chul (Department of Oriental Neuropsychiatry, College of Oriental Medicine, Daejeon University) ;
  • Lee, Sang-Ryong (Department of Oriental Neuropsychiatry, College of Oriental Medicine, Daejeon University)
  • 김영표 (대전대학교 한의과대학 신경정신과학교실) ;
  • 정인철 (대전대학교 한의과대학 신경정신과학교실) ;
  • 이상룡 (대전대학교 한의과대학 신경정신과학교실)
  • Published : 2005.02.25
Download PDF
⟨ Previous Next ⟩

Abstract

This experiment was designed to investigate the effect of Phellodendron amurense(PLDA) on the Alzheimer's disease. The effects of PLDA extract on $IL-1{\beta}$, IL-6, amyloid precursor proteins(APP), acetylcholinesterase(AChE), glial fibrillary acidic protein(GFAP) mRNA of PC-12 cell treated by $A{\beta}$ plus $rIL-1{\beta}$ and AChE activity of PC-12 cell lysate treated by $A{\beta}$ plus $rIL-1{\beta}$ and behavior of memory deficit mice induced by scopolamine and mice glucose, uric acid, AChE activity of memory deficit rats induced by scopolamine were investigated, respectively. PLDA extract suppressed $IL-1{\beta}$, IL-6, APP, AChE, GFAP mRNA in PC-12 cell treated by $A{\beta}$ plus $rIL-1{\beta}$ ; AChE activity in cell lysate of PC-12 cell treated by $A{\beta}$ plus $rIL-1{\beta}$. PLDA extract increased glucose, decreased uric acid and AChE significantly in the serum of the memory deficit rats induced by scopolamine. PLDA extract group showed significantly inhibitory effect on the memory deficit of mice induced by scopolamine in the experiment of Morris water maze. According to the above results, it is suggested that PLDA extract might be usefully applied for prevention and treatment of Alzheimer's disease.

Keywords

References

  1. 金知赫, 黃義完 : 東醫精神醫學, 서울, 現代醫學書籍社, pp. 256-271, 327-330, 1992.
  2. 이광우, 정희원 : 임상신경학, 서울, 고려의학, pp.199-210, 1997.
  3. Selkoe DJ : The cell biology of beta-amyloid precursor protein and presenilin in Alzheimer's disease. Trends Cell Biol, 8(11):447-453, 1998. https://doi.org/10.1016/S0962-8924(98)01363-4
  4. Pyo H, Joe E, Jung S, Lee SH, Jou I : Gangliosides activate cultured rat brain microglia. J Biol Chem, 274(49):34584-34589, 1999. https://doi.org/10.1074/jbc.274.49.34584
  5. Kuhl DE, Koeppe RA, Minoshima S, Snyder SE, Ficaro EP, Foster NL, Frey KA , Kilbourn MR : In vivo mapping of cerebral acetylcholinesterase activity in aging and Alzheimer's disease. Neurology, 52(4):691-699, 1999. https://doi.org/10.1212/WNL.52.4.691
  6. 張介賓: 張氏景岳全書, 서울, 翰成社, pp.610-611, 1978.
  7. 陳士澤: 國譯石室秘錄, 서울, 書苑堂, p.102, 1984.
  8. 錢鏡湖: 辨證奇問全書, 台北, 甘地出版社, pp.222-225, 233-235, 1990.
  9. 洪元植 : 精校黃帝內經素問, 서울, 東洋醫學研究院, p.37, 124, 196, 229, pp.217-218, p.229, 1985.
  10. 洪元植: 精校黃帝內經靈樞, 서울, 東洋醫學研究院, p.68, 342, 1985.
  11. 孫恩邈: 備急千金要方, 서울, 杏林出版社, pp .129-135, p.534, 545, 550, 1982.
  12. 趙 佶; 聖濟總錄, 北京, 人民衛生出版社, pp.822-825, 1987.
  13. 朱震亨 : 全匱鉤玄, 서울, 鼎談出版社, p.727, 1992.
  14. 王肯堂: 證治準繩, 서울, 鼎談出版社, pp.306-307, 1992.
  15. 龔廷賢 : 壽世保元, 江蘇城, 江蘇科學技術出版社, p.43, 1980.
  16. 楊恩澎 외 : 中醫臨床大全, 北京, 北京科學技術出版社, pp.224-230, 1991.
  17. 陳 輝 외 : 實用中醫腦病學, 北京, 學苑出版社, pp.242-251, 784-791, 1993.
  18. 黃大東 외 : 實用中醫內科學, 上海, 上海科學技術出版社, pp. 378-381, 1989.
  19. 康秉秀 외: 本草學, 서울, 永林社, pp.180-181, 1992.
  20. 申佶求 : 申民本草學, 서울, 壽文社, pp.641-647, 1988.
  21. 李時珍 : 本草綱目, 山西, 山西科學技術出版社, pp.1545-1547, 1999.
  22. 김보경, 이상룡 : 安神淸腦湯이 Alzheimer's disease 병태 모델의 생화학적 변화 및 기억에 미치는 영향, 東醫生理病理學會誌, 15(5):708-722, 2001.
  23. 정인철, 이상룡 : 導痰益氣活血湯이 알츠하이머 질환 병태 모델의 생화학적 변화 및 행동에 미치는 영향, 東醫生理病理學會誌, 15(2):260-276, 2001.
  24. 하수영, 이상룡 : 加減固本丸이 치매병태모델에 미치는 영향, 동의신경정신과학회지, 13(1):53-77, 2002.
  25. 윤상학 : 香咐子가 癡呆病態모델에 미치는 實驗的 研究, 대전대학교석사학위논문, 2001.
  26. 김현수 : 巴戟天이 癡呆病態모델에 미치는 實驗的 研究, 대전대학교석사학위논문, 2001.
  27. 채종걸, 이상룡 : 山査肉이 CT105로 誘導된 Alzheimer's Disease 病態 모델에 미치는 影響, 동의신경정신과학회지, 13(1):79-115, 2002.
  28. Skehan P, Storeng R, Scudiero D, Monk A, McMahon J, Visca D, Warren JT, Kennedy S, Boyd MR : New colorimetric cytotoxicity assay for anticancer drug screening. J Natl Cancer Inst, 82(13):1107-1112, 1990. https://doi.org/10.1093/jnci/82.13.1107
  29. Zor T, Selinger Z : Linearization of the Bradford protein assay increases its sensitivity ; theoretical and experimental studies. Anal Biochem, 236(2):302-308, 1996. https://doi.org/10.1006/abio.1996.0171
  30. 金宇哲 외 : 統計學概論, 서울, 英志文化社, pp.177-179, 1990.
  31. 서무규 : 성인병﹒노인병학, 서울, 高麗醫學, pp.225-267, 1986.
  32. 裵旿星 : 老人性 痴呆에 關한 體質學的 研究, 大韓韓醫學會誌, 13(2):101-106, 1992.
  33. 이근후 : 최신임상정신의학, 서울, 하나의학사, p.138, pp.216-228, 1986.
  34. 한일우 외 : Alzheimer병의 증상, 계명의대논문집, 16(3): 339-347, 1997.
  35. Reznik-Wolf H, Machado J, Haroutunian V, DeMarco L, Walter GF, Goldman B, Davidson M, Johnston JA, Lannfelt L, Dam SU, Friedman E : Somatic mutation analysis of the APP and Presenilin 1 and 2 genes in Alzheimer's disease brains. J Neurogenet, 12(1):55-65, 1998. https://doi.org/10.3109/01677069809108555
  36. Forsell C, Froelich S, Axelman K, Vestling M, Cowburn RF, Lilius L, Johnston JA, Engvall B, Johansson K, Dahlkild A, Ingelson M, St. George-Hyslop PH, Lannfelt L : A novel pathogenic mutation(Leu262Phe) found in the presenilin 1 gene in early-onset Alzheimer's disease. Neurosci Lett, 234(1):3-6, 1997. https://doi.org/10.1016/S0304-3940(97)00603-4
  37. Multhaup G, Schlicksupp A, Hesse L, et al : The amyloid precursor protein of Alzheimer's disease in the reduction of copper(II) to copper(I). Science, 271(1):1406-1409, 1996.
  38. Breakfield XO and Geller AI : Gene transfer into the nervous system. Mol Neurobiol. 1(4), 339-371, 1989.
  39. Fontana A, Kristensen F, Dubs R, Gemsa D, Weber E : Production of prostaglandin E and an interleukin-1 like factor by cultured astrocytes and C6 glioma cells. J Immunol, 129(6):2413-2419, 1983.
  40. Selmaj K, Shafit-Zagardo B, Aquino DA, Farooq M, Raine CS, Norton WT, Brosnan CF : Tumor necrosis factor-induced proliferation of astrocytes from mature brain is associated with down-regulation of glial fibrillary acidic protein mRNA. J Neurochem, 57(3):823-830, 1991. https://doi.org/10.1111/j.1471-4159.1991.tb08225.x
  41. Simmons ML, Murphy S : Induction of nitric oxide synthase in glial cells. J Neurochem, 59(3):897-905, 1992. https://doi.org/10.1111/j.1471-4159.1992.tb08328.x
  42. Kang J, Park EJ, Jou I, Kim JH, Joe EH : Reactive oxygen species mediate A beta(25-35)-induced activation of BV-2 microglia. Neuroreport, 12(7):1449-1452, 2001. https://doi.org/10.1097/00001756-200105250-00030
  43. Park CH, Kim SH, Choi W, Lee YJ, Kim JS, Kang SS, Suh YH : Novel anticholinesterase and antiamnesic activities of dehydroevodiamine, a constituent of Evodia rutaecarpa. Planta Med, 62(5):405-409, 1996. https://doi.org/10.1055/s-2006-957926
  44. Kuhl DE, Koeppe RA, Minoshima S, Snyder SE, Ficaro EP, Foster NL, Frey KA, Kilbourn MR : In vivo mapping of cerebral acetylcholinesterase activity in aging and Alzheimer's disease. Neurology, 52(4):691-699, 1999. https://doi.org/10.1212/WNL.52.4.691
  45. Raskind MA, Sadowsky CH, Sigmund WR, Beitler PJ, Auster SB : Effect of tacrine on language, praxis, and noncognitive behavioral problems in Alzheimer disease. Arch Neurol, 54(7):836-840, 1997. https://doi.org/10.1001/archneur.1997.00550190026010
  46. Rupniak NM, Tye SJ, Field MJ : Enhanced performance of spatial and visual recognition memory tasks by the selective acetylcholinesterase inhibitor E2020 in rhesus monkeys. Psychopharmacology (Berl), 131(4):406-410, 1997. https://doi.org/10.1007/s002130050310
  47. Messier C : The absence of effect of glucose on memory is associated with low susceptibility to the amnestic effects of scopolamine in a strain of mice. Behav Brain Res, 96(1-2):47-57, 1998.
  48. 이귀녕, 이종순 : 임상병리파일, 서울, 의학문화사, pp.92-96, 1993.
  49. Degrell I, Niklasson F : Purine metabolites in the CSF in presenile and senile dementia of Alzheimer type, and in multi infarct dementia. Arch Gerontol Geriatr, 7(2):173-178, 1998. https://doi.org/10.1016/0167-4943(88)90029-5