보기익혈 복합방, 바이오 큐의 면역조절 효과

Immunomodulatory Effect of Bio-Q, Bokiikhyul Prescription

  • 이효정 (경희대학교 동서의학 대학원) ;
  • 길재호 (경희대학교 체육대학 스포츠의학과) ;
  • 백남인 (경희대학교 생명과학대학) ;
  • 라정찬 (RNL 생명과학㈜) ;
  • 김성훈 (경희대학교 동서의학 대학원)
  • Lee, Hyo-Jung (Department of Oncology, Graduate School of East-West Medical Science, Kyunghee University) ;
  • Khil, Jae-Ho (Department of Sports Medicine, Kyunghee University) ;
  • Baek, Nam-In (School of Biotechnology and Plant Metabolism Research Center, Kyunghee University) ;
  • Ra, Jeong-Chan (RNL Co.) ;
  • Kim, Sung-Hoon (Department of Oncology, Graduate School of East-West Medical Science, Kyunghee University)
  • 발행 : 2005.08.01

초록

Bio-Q is a modified prescription with the activities of supplementing Qi and blood in human body. In the present study, immunomodulatory effect of Bio-Q was examined. After oral administration of Bio-Q for 7 days to Balb/c mice, splenocytes were isolated and immunological experiments were performed. Bio-Q significantly increased the proliferation of splenocytes exposed to concanavalin A (Con A), while it did not in case of lipopolysaccharide (LPS) stimulation. Bio-Q also significantly increased CD3/CD19, CD4/CDB and NK cells by flow cytometric analysis. In addition, Bio-Q significantly enhanced the level of $INF-\gamma$ in splenocytes, but not $TNF-\alpha$ by ELISA. These results strongly suggest that Bio-Q has immunomodulatory activity through the regulation of T cell mediated immune pathway.

키워드

참고문헌

  1. 梁學道. 臨床微生物學 및 免疫學. 新學社, 서울, p 67, 1979
  2. 菊地浩吉會. 最新免疫學(李淵臺譯). 集文堂 ,서울, p 33, 315, 1985.
  3. 서울대학교 의과대학편. 면역학. 서울대학교출판부, p 265, 272, 1989.
  4. 洪元植編. 精校黃帝內經東洋醫學硏究院, 서울, p 13, 69, 318, 1981
  5. 劉正才. 中醫免疫, 中國, 重慶出版社, p 8-13, 1983.
  6. 金光湖 外. 數種韓藥劑가 制癌劑 및 Glucocorticoid의 抗體生産抑制作用에 미치는 影響, 조영식, 博土華甲論文集, p 1041-1051, 1981.
  7. 嚴宗正, 正邪論新釋, 新中醫, 6:5-6, 1984
  8. 沈承抗, 中醫與免疫, 浙江中醫學院報, 14(2):22-24, 1990.
  9. 金德鎬. 歸茸湯이 免疫機能에 미치는 實驗的 硏究, 大韓韓醫學會誌, 6(2):55-63, 1985
  10. 河大有 外. 人蔘에 關한 細菌學 및 免疫學的 硏究, 第 II 報, 人蔘抽出物投與가 細菌感梁에 對한 抵抗에 미치는 影響,全北大學校論文集, 45, 1979.
  11. Artrsson, P., Edman, P. and Ericsson, J.L. E.:Macrophage stimulation with some structurally related polysaccharides. Scand. J .Immunol. 25, 245, 1987.
  12. Petersen, R.D., Reinhold, W. and Tyborczyk, J. Cytokines in cosmetology. cosmetic and Toietries Magazine. 112, 165, 1997.
  13. Goldsby, R.A., Kindt, T.J. and Osborne, B.A. Kuby immunology 4th ed.,W. Freeman and Company, New York, 303, 2000.