Journal of Physiology & Pathology in Korean Medicine (동의생리병리학회지)

The Physiological Society of Korean Medicine and The Society of Pathology in Korean Medicine (대한동의생리학회·한의병리학회)
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Th1 and Th2 cytokine Modulation by Baicalin, Baicalein and Wogonin from Scutellaria Radex on the $CD4^+$ Jurkat T Cells

$CD4^+$ Jurkat T 세포주에서 Th1과 Th2 사이토가인 조절에 미치는 황금 유래 Baicalin, Baicalein 및 Wogonin의 효과

  • Kim Young Jun (Department of Skin & Beauty, Seojeong College) ;
  • Lee Jeong Chi (Department of Skin & Beauty, Seojeong College) ;
  • Kim Hong Yong (Department of Skin & Beauty, Seojeong College) ;
  • Xie Guanghua (Department of General Surgery, Affiliated Hospital of Yanbian University College of Medicine) ;
  • Yun Yong Gab (Department of Oriental medical prescription, Wonkwang University) ;
  • Jang Seon Il (Department of Skin & Beauty, Seojeong College)
  • 김용준 (서정대학 피부미용과) ;
  • 이정치 (서정대학 피부미용과) ;
  • 김홍용 (서정대학 피부미용과) ;
  • 설광화 (중국 연변대학교 의과대학 일반외과) ;
  • 윤용갑 (원광대학교 한의과대학 방제학교실) ;
  • 장선일 (서정대학 피부미용과)
  • Published : 2005.08.01
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Abstract

In the present study, baicalin, baicalein, and wogonin, a major flavone isolated from Scutellaria Radix were examined for their effects on PMA-induced Interlukin-6 (IL-6), $interferon-\gamma(IFN-\gamma)$, tumor necrosis factor $(TNF)-\alpha$, IL-4, IL-10, and IL-13 productions in the PMA-stimulated $CD4^+$ Jurkat T cells. These three compounds inhibited PMA-induced Th1 cytokine $(IL-6,\;IFN-\gamma,\;TNF-\alpha)$ and Th2 cytokine (IL-4 and IL-13) productions in a concentration-dependent manner. But wogonin, but not baicalin baicalein, increased PMA-induced IL-10 production. These results suggest that baicalin, baicalein, and wogonin, a major flavone modulate Th1 and Th2 cytokine productions in $CD4^+$ Jurkat T cells and these properties may contribute to the anti-atopic dermatitis activity of Scutellaria Radix.

Keywords

References

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