Advances in Traditional Medicine

  • 제7권4호
  • /
  • Pages.390-394
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  • 2007
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  • 2662-4052(pISSN)
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  • 2662-4060(eISSN)
경희대학교 융합한의과학연구소 (Kyung Hee Oriental Medicine Research Center)
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Antinociceptive profile of the ethanolic extract of andrographis paniculata in mice

  • Sulaiman, MR (Laboratory of Natural Products, Institute of Biosciences, Universiti Putra Malaysia) ;
  • Sainan, S (Laboratory of Natural Products, Institute of Biosciences, Universiti Putra Malaysia) ;
  • Zakaria, ZA (Department of Biomedical Sciences, Faculty of Medicine Health Sciences, Universiti Putra Malaysia) ;
  • Somchit, MN (Laboratory of Natural Products, Institute of Biosciences, Universiti Putra Malaysia) ;
  • Israf, DA (Laboratory of Natural Products, Institute of Biosciences, Universiti Putra Malaysia) ;
  • Moin, S (Laboratory of Natural Products, Institute of Biosciences, Universiti Putra Malaysia) ;
  • Mohamad, TA Tengky (Department of Biomedical Sciences, Faculty of Medicine Health Sciences, Universiti Putra Malaysia)
  • 발행 : 2007.12.31
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초록

The present study was conducted to evaluate the analgesic activity of ethanolic extract of Andrographis paniculata (AP) in mice. The analgesic investigations were carried out using the acetic acid-induced abdominal writhing and the hot-plate tests. It was demonstrated that intraperitoneal (i.p.) administration of the extract at a dose of 30, 100, 300, 500 mg/kg, produced significant inhibition of abdominal constriction induced with 0.6% (v/v) acetic acid in dosedependent manner. It also demonstrated that the extract produced significant dose-dependent increase in the time of latency to a discomfort reaction in the hot-plate model. In addition, the analgesic effect of the ethanolic extract of AP was significantly reversed by a non-specific opioid receptor antagonist, naloxone. These results indicate that AP has an analgesic effect that was mediated through opioid receptors.

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참고문헌

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