Applied Chemistry for Engineering (공업화학)

The Korean Society of Industrial and Engineering Chemistry (한국공업화학회)
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Preparation and Characterization of EGCG Entrapped Ethosome

EGCG가 포집된 Ethosome의 제조와 특성조사

  • Gwak, Hyo Jung (Department of Applied Chemistry, Dongduk Women's University) ;
  • Jin, Byung Suk (Department of Applied Chemistry, Dongduk Women's University)
  • 곽효정 (동덕여자대학교 응용화학과) ;
  • 진병석 (동덕여자대학교 응용화학과)
  • Received : 2007.01.29
  • Accepted : 2007.02.15
  • Published : 2007.04.10
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Abstract

Entrapment of (-)-epigallocatechin gallate (EGCG) into ethosome was carried out for improving its stability against decomposition. Solubility of EGCG was increased by the addition of ethanol into water, which enable ethosome to entrap appropriate amount of EGCG. It was observed that the EGCG solution concentration and constituent lipid composition had a considerable effect on the particle size and entrapment efficiency of ethosomes. The formation of liquid crystalline phase in ethosome was investigated by polarized optical microscopy. By comparing the stability of EGCG in solution and in ethosome exposed to UV or high temperature, we evaluated the EGCG stabilization effect through its entrapment in ethosome. Incorporation of tocopherol into ethosome retarded the decomposition of EGCG under UV.

EGCG의 안정성을 향상시키기 위해 ethosome에 포집을 시도하였다. 물에 에탄올을 첨가해서 EGCG의 용해도를 높임으로써 ethosome에 적정량의 EGCG이 포집될 수 있도록 하였다. EGCG 수용액의 농도와 ethosome 막을 구성하는 지질의 조성은 ethosome 입자크기와 포집효율에 상당한 영향을 미치는 것을 확인하고 ethosome의 액정상 형성은 편광 현미경을 사용하여 관측하였다. EGCG가 수용액 상태로 있을 때와 ethosome에 포집되어 있을 때, UV 또는 고온의 상태에서의 안정성을 비교한 결과 ethosome에 포집된 EGCG의 안정화 효과를 확인하였다. Ethosome에 토코페롤의 첨가는 UV에 의한 EGCG의 분해를 지연시켰다.

Keywords

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