Journal of Physiology & Pathology in Korean Medicine (동의생리병리학회지)

The Physiological Society of Korean Medicine and The Society of Pathology in Korean Medicine (대한동의생리학회·한의병리학회)
권호 표지

Inhibition of Aqueous Extract from Amomum xanthioides on ${\alpha}$-melnocyte Stimulating Hormone Induced Melanogenesis in B16F10 Cell

사인의 열수 추출물이 B16F10 흑색종세포의 멜라닌형성에 미치는 영향

  • Lee, Soo-Jin (Department of Anatomy, College of Oriental Medicine, Dong -Eui University) ;
  • Ye, Jeong-Sook (Department of Anatomy, College of Oriental Medicine, Dong -Eui University) ;
  • Choi, Yung-Hyun (Department of Biochemistry, College of Oriental Medicine, Dong -Eui University) ;
  • Lee, Yong-Tae (Department of Physiology, College of Oriental Medicine, Dong -Eui University) ;
  • Chung, Kyung-Tae (Department of Life Science and Biotechnology, College of Natural Science, Dong-Eui University) ;
  • Jeong, Seong-Yun (Korea BIO-IT Foundry center, Pusan National University) ;
  • Choi, Byung-Tae (Department of Anatomy, College of Oriental Medicine, Dong -Eui University)
  • 이수진 (동의대학교 한의과대학 해부학교실) ;
  • 예정숙 (동의대학교 한의과대학 해부학교실) ;
  • 최영현 (동의대학교 한의과대학 생화학교실) ;
  • 이용태 (동의대학교 한의과대학 생리학교실) ;
  • 정경태 (동의대학교 자연과학대학 생명응용과학과) ;
  • 정성윤 (부산대학교 BIT융합기술산업화지원기반구축사업단) ;
  • 최병태 (동의대학교 한의과대학 해부학교실)
  • Published : 2007.02.25
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Abstract

To develope skin-whitening or therapeutic agents against hyperpigmentation, aqueous extract from Amomum xanthioides (AEAX) was evaluated for melanogenesis inhibitory activity in B16F10 melanoma cell. The treatment with AEAX at the 0.5 and 1.0 mg/ml level significantly inhibits the biosynthesis of melanin compared with untreated control. The AEAX-treated cells at the 1.0 mg/ml level were more efficient than commercial arbutin at 0.1 mg/ml. The tyrosinase activity also significantly decreased in AEAX-treated cells at the 0.5 and 1.0 mg/ml level. The Western analyses confirmed the significantly decreased expression of tyrosinase and tyrosinase-related protein-1 by AEAX treatment. These results indicate that AEAX may contribute to the inhibition of melanin biosynthesis through regulating tyrosinase activity and expression and serve as a new candidate in the design of new skin-whitening or therapeutic agents.

Keywords

References

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