Advances in Traditional Medicine

Kyung Hee Oriental Medicine Research Center (경희대학교 융합한의과학연구소)
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Protective effects of Polygala tenuifolia on ischemia-induced 4 vessel occlusion in rats

  • Kim, Young-Ock (Ginseng & Medicinal Crops Division, National Institute of Crop Science, Rural Development Administration) ;
  • Kim, Su-Kang (Kohwang Medical Research Institute, Department of Pharmacology, School of Medicine, Kyung Hee University) ;
  • Cho, Ah-Rang (Kohwang Medical Research Institute, Department of Pharmacology, School of Medicine, Kyung Hee University) ;
  • Chung, Joo-Ho (Kohwang Medical Research Institute, Department of Pharmacology, School of Medicine, Kyung Hee University)
  • Published : 2008.02.29
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Abstract

The root of Polygala tenuifolia Willd (PT) is known to have neuroprotective effects and as an antidementic herb in Chinese and Japanese traditional medicine. We examined potential neuroprotective effects of PT using the 4-vessel occlusion model in rats. In this study, the efficacy of PT for the prevention of neuronal damage and for the reduction of memory impairment was investigated. The results indicate that PT confers significant neuroprotection especially for ischemic hippocampal neurons.

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References

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