Journal of Physiology & Pathology in Korean Medicine (동의생리병리학회지)

The Physiological Society of Korean Medicine and The Society of Pathology in Korean Medicine (대한동의생리학회·한의병리학회)
권호 표지

Anti-inflammatory Effects of Sophora Japonica Aqueous Extract

괴화(槐花) 물 추출물의 항염증 효과

  • Bae, Gi-Sang (Department of Herbology, College of Oriental Medicine, Wonkwang University) ;
  • Jo, Beom-Yeon (Department of Herbology, College of Oriental Medicine, Wonkwang University) ;
  • Kim, Min-Sun (Department of Herbology, College of Oriental Medicine, Wonkwang University) ;
  • Park, Kyoung-Chel (Department of Herbology, College of Oriental Medicine, Wonkwang University) ;
  • Koo, Bon-Soon (Department of Herbology, College of Oriental Medicine, Wonkwang University) ;
  • Seo, Sang-Wan (ChungBuk Oriental Medicine Center) ;
  • Kim, Sung-Gyu (ChungBuk Oriental Medicine Center) ;
  • Yun, Seung-Won (ChungBuk Oriental Medicine Center) ;
  • Jung, Won-Seok (Division of Constitutional Medicine Research, Korea Institute of Oriental Medicine) ;
  • Ham, Kyung-Wan (Department of Herbology, College of Oriental Medicine, Wonkwang University) ;
  • Song, Ho-Joon (Department of Herbology, College of Oriental Medicine, Wonkwang University) ;
  • Youn, Myung-Ja (Vestibulocochlear Research Center, College of Medicine, Wonkwang University) ;
  • Jeon, Ho-Seong (Professional Graduate School of Oriental Medicine, Wonkwang University) ;
  • Kwon, Kang-Beom (Department of Physiology, College of Oriental Medicine, Wonkwang University) ;
  • Kim, Jae-Hyo (Department of Meridian & Acupoint, College of Oriental Medicine, Wonkwang University) ;
  • Park, Sung-Joo (Department of Herbology, College of Oriental Medicine, Wonkwang University)
  • 배기상 (원광대학교 한의과대학 본초학교실) ;
  • 조범연 (원광대학교 한의과대학 본초학교실) ;
  • 김민선 (원광대학교 한의과대학 본초학교실) ;
  • 박경철 (원광대학교 한의과대학 본초학교실) ;
  • 구본순 (원광대학교 한의과대학 본초학교실) ;
  • 서상완 (충북 제천 전통의약 산업센터) ;
  • 김성규 (충북 제천 전통의약 산업센터) ;
  • 윤승원 (충북 제천 전통의약 산업센터) ;
  • 정원석 (전남 한방 산업 진흥원) ;
  • 함경완 (원광대학교 한의과대학 본초학교실) ;
  • 송호준 (원광대학교 한의과대학 본초학교실) ;
  • 윤명자 (원광대학교 의과대학 전정와우 연구센터) ;
  • 전호성 (원광대학교 한의학전문대학원 제3의학과) ;
  • 권강범 (원광대학교 한의과대학 한방생리학교실) ;
  • 김재효 (원광대학교 한의과대학 경혈학교실) ;
  • 박성주 (원광대학교 한의과대학 본초학교실)
  • Published : 2009.12.25
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Abstract

The purpose of this study was to investigate the anti-inflammatory effects of aqueous extract from Sophora Japonica (SJ) on the RAW 264.7 cells. To evaluate the anti-inflammatory effects of SJ, we examined the cytokine productions including nitric oxide (NO), interleukin (IL)-1b, IL-6 and tumor necrosis factor-a (TNF-a) in lipopolysaccharide (LPS)-induced RAW 264.7 cells and also inhibitory mechanisms such as mitogen-activated protein kinases (MAPKs) and nuclear factor kappa b (NF-kB) using Western blot. SJ inhibited LPS-induced production of NO, TNF-a but not of IL-1b and IL-6 in RAW 264.7 cells. SJ inhibited the activation of MAPKs such as extracelluar signal-regulated kinase (ERK 1/2), c-Jun NH2-terminal kinase (JNK) and p38 but not of NF-kB in the LPS-stimulated RAW 264.7 cells. In conclusion, SJ down-regulated LPS-induced NO and TNF-a productions via MAPKs, which could be a clinical basis for inflammatory diseases and autoimmune diseases.

Keywords

References

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