Journal of Physiology & Pathology in Korean Medicine (동의생리병리학회지)

The Physiological Society of Korean Medicine and The Society of Pathology in Korean Medicine (대한동의생리학회·한의병리학회)
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Anti-inflammatory Effect of Potentillae Chinensis Herba Water Extract on the Proteinase-activated Receptor2-mediated Paw Edema

Proteinase 활성수용체-2로 유발된 백서족척 부종에 미치는 위릉채의 항염효과

  • Lim, Jong-Pil (College of Pharmacy, Woosuk University) ;
  • Lee, Hong-Kyu (College of Pharmacy, Woosuk University) ;
  • Jeon, Hoon (College of Pharmacy, Woosuk University) ;
  • Lim, Bo-Ra (Department of Experimental Therapeutics, School of Medicine, University of Pennsylvania)
  • Published : 2009.12.25
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Abstract

Potentilla chinensis Ser. (Rosaceae) has long been used for a remedy of diarrhea and inflammation in Korea. In this study, the anti-inflammatory effects of the Potentillae chinensis Herba water extract (PCX) was investigated in proteinase-activated receptor-2 (PAR2)-mediated rat paw edema. Paw edema was induced by injection of trypsin or trans-cinnamoyl-LIGRLO-$NH_2$ (tc-$NH_2$) into the hind paw of rats. PCX (10, 50, 100 and 200 mg/kg) was orally administered 1 h before the induction of inflammation. At doses of 50, 100 and 200 mg/kg, PCX showed significant inhibition on both change in paw volume and vascular permeability. PCX (100 mg/kg) significantly inhibited PAR2 agonists-induced myeloperoxidase (MPO) activity in paw tissue. These results indicate that PCX has an anti-inflammatory action in PAR2-mediated paw edema.

Keywords

References

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