Journal of Physiology & Pathology in Korean Medicine (동의생리병리학회지)

The Physiological Society of Korean Medicine and The Society of Pathology in Korean Medicine (대한동의생리학회·한의병리학회)
권호 표지

Anti-inflammatory Effects of Belamcanda Chinensis Water Extract

사간 물 추출물의 항염증 효과

  • Park, Sung-Joo (Department of Herbology, College of Oriental Medicine, Wonkwang University) ;
  • Kim, Soo-Kon (Deparment of Radiation Oncology, Kangwon National University Hospital)
  • 박성주 (원광대학교 한의과대학 본초학교실) ;
  • 김수곤 (강원대학교병원 방사선종양학과)
  • Received : 2010.05.25
  • Accepted : 2010.06.04
  • Published : 2010.06.25
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Abstract

The purpose of this study was to investigate the anti-inflammatory effects of aqueous extract from Belamcanda chinensis (BC) on the RAW 264.7 cells. To evaluate the anti-inflammatory effects of BC, we examined the cytokine productions including nitric oxide (NO), interleukin (IL)-1b, IL-6 and tumor necrosis factor-a (TNF-a) in lipopolysaccharide (LPS)-induced RAW 264.7 cells and also inhibitory mechanisms such as mitogen-activated protein kinases (MAPKs) and nuclear factor kappa B (NF-kB) using Western blot. BC inhibited LPS-induced production of NO, IL-6 and TNF-a but not of IL-1b in RAW 264.7 cells. BC respectively inhibited the activation of MAPKs such as c-Jun NH2-terminal kinase (JNK) and p38 but not of extracelluar signal-regulated kinase (ERK 1/2) and NF-kB in the LPS-stimulated RAW 264.7 cells. Taken together, Our results showed that BC down-regulated LPS-induced NO, IL-6 and TNF-a productions mainly through JNK and p38 MAPK pathway.

Keywords

References

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