Journal of Physiology & Pathology in Korean Medicine (동의생리병리학회지)

The Physiological Society of Korean Medicine and The Society of Pathology in Korean Medicine (대한동의생리학회·한의병리학회)
권호 표지

Inhibitory Effect of Gamigunggui-tang on Allergic Contact Dermatitis

알레르기성 접촉성 피부염에 대한 가미궁귀탕(加味芎歸湯)의 억제효과

  • Ahn, Ji-Young (Department of Oriental Pharmacy, College of Pharmacy, Wonkwang University and Wonkwang-Oriental Medicines Research Institute) ;
  • Im, Lee-Rang (Department of Oriental Pharmacy, College of Pharmacy, Wonkwang University and Wonkwang-Oriental Medicines Research Institute) ;
  • Kim, Jun-Ho (Department of Oriental Pharmacy, College of Pharmacy, Wonkwang University and Wonkwang-Oriental Medicines Research Institute) ;
  • Xin, Ming-Jie (Department of Oriental Pharmacy, College of Pharmacy, Wonkwang University and Wonkwang-Oriental Medicines Research Institute) ;
  • Kwon, Se-Uk (Department of Oriental Pharmacy, College of Pharmacy, Wonkwang University and Wonkwang-Oriental Medicines Research Institute) ;
  • Kim, Dae-Keun (College of Life Science and Natural Resources) ;
  • Song, Bong-Suk (Department of Oriental Pharmacy, College of Pharmacy, Wonkwang University and Wonkwang-Oriental Medicines Research Institute) ;
  • Song, Bong-Jun (Department of Oriental Pharmacy, College of Pharmacy, Wonkwang University and Wonkwang-Oriental Medicines Research Institute) ;
  • Jung, Hyun-Ju (Department of Oriental Pharmacy, College of Pharmacy, Wonkwang University and Wonkwang-Oriental Medicines Research Institute) ;
  • Hong, Seung-Heon (Department of Oriental Pharmacy, College of Pharmacy, Wonkwang University and Wonkwang-Oriental Medicines Research Institute) ;
  • Kwon, Dong-Yeul (Department of Oriental Pharmacy, College of Pharmacy, Wonkwang University and Wonkwang-Oriental Medicines Research Institute) ;
  • Kim, Yun-Kyung (Department of Oriental Pharmacy, College of Pharmacy, Wonkwang University and Wonkwang-Oriental Medicines Research Institute) ;
  • Kim, Dae-Ki (Department of Immunology, Medical School, Chonbuk National University) ;
  • Lee, Young-Mi (Department of Oriental Pharmacy, College of Pharmacy, Wonkwang University and Wonkwang-Oriental Medicines Research Institute)
  • 안지영 (원광대학교 약학대학 한약학과 및 원광한약연구소) ;
  • 임이랑 (원광대학교 약학대학 한약학과 및 원광한약연구소) ;
  • 김준호 (원광대학교 약학대학 한약학과 및 원광한약연구소) ;
  • 신명걸 (원광대학교 약학대학 한약학과 및 원광한약연구소) ;
  • 권세욱 (원광대학교 약학대학 한약학과 및 원광한약연구소) ;
  • 김대근 (진안군홍삼한방클러스터사업단) ;
  • 송봉석 (원광대학교 약학대학 한약학과 및 원광한약연구소) ;
  • 송봉준 (원광대학교 약학대학 한약학과 및 원광한약연구소) ;
  • 정현주 (원광대학교 약학대학 한약학과 및 원광한약연구소) ;
  • 홍승헌 (원광대학교 약학대학 한약학과 및 원광한약연구소) ;
  • 권동렬 (원광대학교 약학대학 한약학과 및 원광한약연구소) ;
  • 김윤경 (원광대학교 약학대학 한약학과 및 원광한약연구소) ;
  • 김대기 (전북대학교 의학전문대학원) ;
  • 이영미 (원광대학교 약학대학 한약학과 및 원광한약연구소)
  • Received : 2010.03.22
  • Accepted : 2010.04.13
  • Published : 2010.04.25
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Abstract

Gamigunggui-tang (GMGGT) is one of the important prescriptions that has been used in oriental medicine. We investigated the inhibitory effect of an oral administration of hot water extract of GMGGT on the development of atopic dermatitis (AD) by using Balb/c mice. The induction of atopic dermatitis-like lesion was conducted by the removal of the back hairs and topical application of 2,4-Dinitrochlorobenzene (DNCB) on to the back skin repeatedly. GMGGT was orally administered at a different dose (10.0 mg/kg, 50.0 mg/kg). Skin reactions, consisting of increased ear thickness and the presence of ear inflammation, were observed in mice over three weeks. Oral administration of GMGGT significantly suppressed the skin lesions, ear swelling, spleen weight, total serum IgE in a concentration dependent manner, and also inhibited the infiltration of mast cells in the dorsal skin. In the present study, these results suggested that GMGGT extract inhibits inflammatory response atopic dermatitis. Therefore, GMGGT may be effective substances for the management of AD in human.

Keywords

References

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