Asian Pacific Journal of Cancer Prevention

Asian Pacific Journal of Cancer Prevention (아시아태평양암예방학회)
권호 표지
DOI QR코드

DOI QR Code

Second Primary Malignant Neoplasms: A Clinicopathological Analysis from a Cancer Centre in India

  • Hulikal, Narendra (Department of Surgical Oncology, Sri Venkateswara Institute of Medical Sciences, SVIMS) ;
  • Ray, Satadru (Surgical Oncology, Kasturba Medical College, Manipal University) ;
  • Thomas, Joseph (Medical Oncology, Kasturba Medical College, Manipal University) ;
  • Fernandes, Donald J. (Radiation Oncology, Kasturba Medical College, Manipal University)
  • Published : 2012.12.31
Download PDF
⟨ Previous Next ⟩

Abstract

Context: Patients diagnosed with a cancer have a life time risk of developing another de novo malignancy depending on various inherited, environmental and iatrogenic risk factors. Of late the detection of new primary has increased mainly due to refinement in both diagnostic and treatment modalities. Cancer victims are surviving longer and thus are more likely to develop a new metachronous malignancy. Aims: To report our observed trend of increase in prevalence of both synchronous and metachronous second malignant neoplasms among cancer victims and to review the relevant literature. Settings and Design: A hospital based retrospective collection of prospective data of patients diagnosed with second denovo malignancy. Materials and Method: The study was conducted over a 5 year period from July 2008 to June 2012. All patients diagnosed with a histologically proven second malignancy as per Warren Gate's criteria were included. Various details regarding sex, age at presentation, synchronous or metachronous, treatment and outcome were recorded. Conclusions: The occurrence of multiple primary malignancies is not rare. Awareness of the possibility alerts the clinician in evaluation of patients with a known malignancy presenting with unusual sites of metastasis. Individualizing the treatment according to the stages of the primaries will result in durable cancer control particularly in synchronous double malignancy.

Keywords

References

  1. Agrawal R (2007). Synchronous dual malignancy: successfully treated cases. J Cancer Res Ther, 3, 153-6. https://doi.org/10.4103/0973-1482.37408
  2. Amemiya K, Shibuya H, Yoshimura R, Okada N (2005). The risk of radiation-induced cancer in patients with squamous cell carcinoma of the head and neck and its results of treatment. Br J Radiol, 78, 1028-33 https://doi.org/10.1259/bjr/86352309
  3. Aydiner A, Karadeniz A, Uygun K, et al (2000). Multiple primary neoplasms at a single institution: differences between synchronous and metachronous neoplasms. Am J Clin Oncol, 23, 364-70. https://doi.org/10.1097/00000421-200008000-00011
  4. Berg JW, Schottenfeld D (1977). Multiple primary cancers at memorial hospital 1949-1962. Cancer, 40, 1801-5. https://doi.org/10.1002/1097-0142(197710)40:4+<1801::AID-CNCR2820400805>3.0.CO;2-G
  5. Berge T, Cederqvist L, Schonebeck J (1969). Multiple primary malignant tumors: an autopsy study of a circumscribed population. Acta Pathol Microbiol Scand, 76, 171-83.
  6. Bordin GM, Key CR, McQuade CE, et al (1977). Multiple primary cancers: relative risk in New Mexico's triethnic population. Cancer, 40, 1793-800. https://doi.org/10.1002/1097-0142(197710)40:4+<1793::AID-CNCR2820400804>3.0.CO;2-7
  7. Cheng HY, Chu CH, Chang WH, et al (2005). Clinical analysis of multiple primary malignancies in the digestive system: a hospital-based study. World J Gastroenterol, 11, 4215-9.
  8. Curtis RE, Ries LA: Methods, in Curtis RE, Freedman DM, Ron E, et al (eds): New Malignancies Among Cancer Survivors: SEER Cancer Registries, 1973-2000. Bethesda, MD, National Cancer Institute, 2006, pp 9-14.
  9. Day GL, Blot WJ, Shore RE, et al (1994). Second cancers following oral and pharyngeal cancers: role of tobacco and alcohol. J Natl Cancer Inst, 86, 131-7. https://doi.org/10.1093/jnci/86.2.131
  10. Day GL, Blot WJ, Shore RE, et al (1994). Second cancers following oral and pharyngeal cancer: patients' characteristics and survival patterns. Eur J Cancer B Oral Oncol, 30, 381-6. https://doi.org/10.1016/0964-1955(94)90016-7
  11. Engin K (1994). Cancers in multiple primary sites. Int Surg, 79, 33-7.
  12. Flannery JT, Boice JD Jr, Devesa SS, et al (1985). Cancer registration in connecticut and the study of multiple primary cancers, 1935-82. Natl Cancer Inst Monogr, 68, 13-24.
  13. Gluckman JT, Crissman JD (1983). Survival rates in 548 patients with multiple neoplasmas of the upper aerodigestive tract. Laryngoscope, 93, 71-4.
  14. Gursel B, Meydan D, Ozbek N, Ozdemir O, Odabas E (2011). Multiple primary malignant neoplasms from the black sea region of Turkey. J Int Med Res, 39, 667-74. https://doi.org/10.1177/147323001103900237
  15. Haddow AJ, Boyd JF, Graham AC (1972). Multiple primary neoplasms in the western hospital region, scotland: a survey based on cancer registration data. Scott Med J, 17, 143-52.
  16. Hadju SI, Hadju EO (1968). Multiple primary malignant tumors. J Am Geriatr Soc, 16, 16-26.
  17. Ishimori T, Patel PV, Wahl RL (2005). Detection of unexpected additional primary malignancies with PET/CT. J Nucl Med, 46, 752-7.
  18. Khuri FR, Kim ES, Lee JJ, et al (2001). The impact of smoking status, disease stage, and index tumor site on second primary tumor incidence and tumor recurrence in the head and neck retinoid chemoprevention trial. Cancer Epidemiol Biomarkers Prev, 10, 823-9.
  19. Lee TK, Myers RT, Scharyj M, Marshall RB (1982). Multiple primary malignant tumors (MPMT): study of 68 autopsy cases (1963-1980). J Am Geriatr Soc, 30, 744-53.
  20. Leon X, Quer M, Diez S, et al (1999). Second neoplasm in patients with head and neck cancer. Head Neck, 21, 204-10. https://doi.org/10.1002/(SICI)1097-0347(199905)21:3<204::AID-HED4>3.0.CO;2-7
  21. Moertel CG, Dockerty MB, Baggenstoss AH (1961). Multiple primary malignant neoplasms. II. Tumors of different tissues or organs. Cancer, 14, 231-7. https://doi.org/10.1002/1097-0142(196103/04)14:2<231::AID-CNCR2820140203>3.0.CO;2-2
  22. Moertel CG (1977). Multiple primary malignant neoplasms: Historical perspectives. Cancer, 40, 1786-92. https://doi.org/10.1002/1097-0142(197710)40:4+<1786::AID-CNCR2820400803>3.0.CO;2-2
  23. Morris LGT, Sikora AG, Patel SG, Hayes RB, Ganly I (2010). Second primary cancers after an index head and neckcancer: subsite-specific trends in the era of human papillomavirus-associated oropharyngeal cancer. J Clin Oncol, 29, 739-46.
  24. Morris LG, Sikora AG, Hayes RB, Patel SG, Ganly I (2011). Anatomic sites at elevated risk of second primary cancer after an index head and neck cancer. Cancer Causes Control, 22, 671-9. https://doi.org/10.1007/s10552-011-9739-2
  25. Narendra H, Vinayak R, Thomas J (2012). Incidental intraoperative discovery of colonic growth in a patient with esophageal carcinoma-lessons learnt! Ind J Surg, 10, 1007.
  26. Newell GR, Krementz ET (1977). Multiple malignant neoplasms in the charity hospital of louisiana tumor registry. Cancer, 40, 1812-20. https://doi.org/10.1002/1097-0142(197710)40:4+<1812::AID-CNCR2820400807>3.0.CO;2-6
  27. Oddou S, Vey N, Viens P, et al (1998). Second neoplasm following high-dose chemotherapy and autologous stem cell transplantation for malignant lymphoma : a report of six cases in a cohort of 171 patients from a single institution. Leukemia and Lymphoma, 31, 187-94. https://doi.org/10.3109/10428199809057598
  28. Poon RT, Law SY, Chu KM, Branicki FJ, Wong J (1998). Multiple primary cancers in esophageal squamous cell carcinoma: incidence and implications. Ann Thorac Surg, 65, 1529-34. https://doi.org/10.1016/S0003-4975(98)00177-5
  29. Van der Sijp JR, van Meerbeeck JP, Maat AP, et al (2002). Determination of the molecular relationship between multiple tumors within one patient is of clinical importance. J Clin Oncol, 20, 1105-14. https://doi.org/10.1200/JCO.20.4.1105
  30. Spratt JS, Hoag MG (1966). Incidence of multiple primary cancers per man-year of follow up: 20-year review from the Ellis Fischel State Cancer Hospital. Ann Surg, 164, 775-84. https://doi.org/10.1097/00000658-196611000-00001
  31. Storm HH, Jensen OM, Ewertz M, et al (1985). Summary: multiple primary cancers in Denmark, 1943-80. Natl Cancer Inst Monogr, 68, 411-30.
  32. Sturgis EM, Miller RH (1995). Second primary malignancies in the head and neck cancer patient. Ann Otol Rhinol Laryngol, 104, 946-54. https://doi.org/10.1177/000348949510401206
  33. Suzuki S, Nishimaki T, Suzuki T, et al (2002). Outcomes of simultaneous resection of synchronous esophageal and extra esophageal carcinomas. J Am Coll Surg, 195, 23-9. https://doi.org/10.1016/S1072-7515(02)01147-X
  34. Suzuki T, Takahashi H, Yao K, et al (2002). Multiple primary malignancies in the head and neck: a clinical review of 121 patients. Acta Oto-Laryngologica Supp, 547, 88-92.
  35. Teppo L, Pukkala E, Saxen E (1985). Multiple cancer-an epidemiologic exercise in Finland. J Natl Cancer Inst, 75, 207-17.
  36. Tepperman BS, Fitzpatrick PJ (1981). Second respiratory and upper digestive tract cancers after oral cancer. Lancet, 2, 547-9.
  37. Warren S, Gates O (1932). Multiple primary malignant tumors: A survey of the literature and statistical study. Am J Cancer, 16, 1358-414.
  38. Watanabe S, Kodama T, Shimosato Y, et al (1984). Multiple primary cancers in 5,456 autopsy cases in the national cancer center of Japan. J Natl Cancer Inst, 72, 1021-27.
  39. Yamamoto E, Shibuya H, Yoshimura R, Miura M (2002). Site specific dependency of second primary cancer in early stage head and neck squamous cell carcinoma. Cancer, 94, 2007-14. https://doi.org/10.1002/cncr.10444

Cited by

  1. Multidisciplinary treatment based on surgery leading to long-term survival of a patient with multiple asynchronous rare primary malignant neoplasms: A case report and literature review pp.1792-1082, 2014, https://doi.org/10.3892/ol.2014.2833
  2. Primary alveolar soft part sarcoma of the right femur and primary lymphoma of the left femur: A case report and literature review vol.11, pp.1, 2015, https://doi.org/10.3892/ol.2015.3906
  3. Multiple Primary Malignancies: Metastatic Renal with Early Breast and Endometrial Cancers: A Case Report vol.09, pp.11, 2018, https://doi.org/10.4236/jct.2018.911075