The Korean Journal of Physiology and Pharmacology

The Korean Society of Pharmacology (대한약리학회)
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Impact of Micellar Vehicles on in situ Intestinal Absorption Properties of Beta-Lapachone in Rats

  • Jang, Soung Baek (College of Pharmacy, Chung-Ang University) ;
  • Kim, Dongju (College of Pharmacy, Chung-Ang University) ;
  • Kim, Seong Yeon (College of Pharmacy, Chung-Ang University) ;
  • Park, Changhee (College of Pharmacy, Chung-Ang University) ;
  • Jeong, Ji Hoon (Department of Pharmacology, College of Medicine, Chung-Ang University) ;
  • Kuh, Hyo-Jeong (Department of Biomedical Science, College of Medicine, The Catholic University of Korea) ;
  • Lee, Jaehwi (College of Pharmacy, Chung-Ang University)
  • Received : 2012.09.06
  • Accepted : 2013.01.14
  • Published : 2013.02.28
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Abstract

The aim of the present study was to examine the effect of micellar systems on the absorption of beta-lapachone (b-lap) through different intestinal segments using a single-pass rat intestinal perfusion technique. B-lap was solubilized in mixed micelles composed of phosphatidylcholine and sodium deoxycholate, and in sodium lauryl sulfate (SLS)-based conventional micelles. Both mixed micelles and SLS micelles improved the in situ permeability of b-lap in all intestinal segments tested although the mixed micellar formulation was more effective in increasing the intestinal absorption of b-lap. The permeability of b-lap was greatest in the large intestinal segments. Compared with SLS micelles, the effective permeability coefficient values measured with mixed micelles were 5- to 23-fold higher depending on the intestinal segment. Our data suggest that b-lap should be delivered to the large intestine using a mixed micellar system for improved absorption.

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References

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