The Korean Journal of Physiology and Pharmacology

  • 제17권5호
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  • Pages.423-426
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  • 2013
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  • 1226-4512(pISSN)
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  • 2093-3827(eISSN)
대한약리학회 (The Korean Society of Pharmacology)
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Estrogen Rather Than Progesterone Cause Constipation in Both Female and Male Mice

  • Oh, Ji-Eun (Obesity-Diabetes Advanced Research Center, School of Medicine, Yeungnam University) ;
  • Kim, Yong-Woon (Obesity-Diabetes Advanced Research Center, School of Medicine, Yeungnam University) ;
  • Park, So-Young (Obesity-Diabetes Advanced Research Center, School of Medicine, Yeungnam University) ;
  • Kim, Jong-Yeon (Obesity-Diabetes Advanced Research Center, School of Medicine, Yeungnam University)
  • 투고 : 2013.06.03
  • 심사 : 2013.07.15
  • 발행 : 2013.10.30
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초록

Females are more often affected by constipation than males, especially during pregnancy, which is related to the menstrual cycle. Although still controversial, alterations of progesterone and estrogen may be responsible. Therefore, this study was conducted in order to determine whether the female sex steroid hormone itself is responsible for development of constipation in both female and male mice. Administration of estrogen resulted in a decrease in weight of accumulated feces on days 2, 3, 4, and 5 in male mice and on day 5 in female mice, compared with the control group, but progesterone administration did not. Administration of estrogen resulted in a decrease in gastrointestinal movement, compared to normal; however, no significant change was observed by administration of progesterone. In conclusion, estrogen, rather than progesterone, may be a detrimental factor of constipation via decreased bowel movement in mice.

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피인용 문헌

  1. Constipation and diarrhea during the menopause transition and early postmenopause: observations from the Seattle Midlife Women's Health Study vol.25, pp.6, 2018, https://doi.org/10.1097/gme.0000000000001057
  2. Isobaric tags for relative and absolute quantification-based proteomic analysis that reveals the roles of progesterone receptor, inflammation, and fibrosis for slow-transit constipation : Slow-transit vol.33, pp.2, 2013, https://doi.org/10.1111/jgh.13873
  3. Uncovering the Mechanisms of Chinese Herbal Medicine (MaZiRenWan) for Functional Constipation by Focused Network Pharmacology Approach vol.9, pp.None, 2013, https://doi.org/10.3389/fphar.2018.00270
  4. Constipation in adults vol.3, pp.None, 2013, https://doi.org/10.31146/1682-8658-ecg-175-3-10-33