The Korean Journal of Physiology and Pharmacology

The Korean Society of Pharmacology (대한약리학회)
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Alcohol-induced Hyperlipidemia Is Ameliorated by Orally Administered DWP208, a Sodium Succinate Form of ZYM201

  • Cho, Jae Youl (Department of Genetic Engineering, Sungkyunkwan University) ;
  • Choi, Jongwon (College of Pharmacy, Kyungsung University) ;
  • Park, Jae Gwang (Department of Genetic Engineering, Sungkyunkwan University) ;
  • Yi, Young-Su (Department of Genetic Engineering, Sungkyunkwan University) ;
  • Hossen, Muhammad Jahangir (Department of Genetic Engineering, Sungkyunkwan University) ;
  • Kim, Hyeongmin (College of Pharmacy, Chung-Ang University) ;
  • Ro, Jieun (College of Pharmacy, Chung-Ang University) ;
  • Cha, Bae Cheon (College of Health Sciences, Sangji University) ;
  • Yoo, Eun Sook (College of Medicine, Jeju National University) ;
  • Kim, Jong-Hoon (College of Veterinary Medicine, Biosafety Research Institute, Chonbuk National University) ;
  • Lee, Jaehwi (College of Pharmacy, Chung-Ang University)
  • Received : 2014.04.25
  • Accepted : 2014.09.05
  • Published : 2014.12.30
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Abstract

DWP208 is a sodium succinate form of ZYM-201 which is a triterpenoid glycoside isolated from Sanguisorba officinalis, a medicinal plant prescribed for various diseases, such as duodenal ulcers and bleeding in East Asian counties. We demonstrated that this compound is able to normalize the altered lipid metabolism induced by hyperglycemia and a high fat diet. In this study, we determined whether hyperlipidemic conditions induced with chronically treated alcohol can also be restored by DWP208. Similar to our previous results, orally administered DWP208 (1 to 10 mg/kg) also ameliorated the hyperlipidemia that was induced by alcohol. This compound reversed the alcohol-induced hyperlipidemia including (i) up-regulated hyperlipidemic parameters such as low-density lipoprotein (LDL), very low-density lipoprotein (VLDL), atherosclerotic index (AI), triglyceride, and total cholesterol, and (ii) down-regulated hyperlipidemic parameters such as absolute body weight, superoxide dismutase (SOD) activity, and high-density lipoprotein (HDL) in serum and liver. According to our data, the ameliorative activity of DWP208 is due to its indirect anti-oxidative activity as a result of which lipid peroxide and hydroxyl radical levels were reduced and the activity of SOD was enhanced. Therefore, our data strongly suggest that DWP208 can be used as a remedy against alcohol-induced hyperlipidemia.

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References

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