Journal of Physiology & Pathology in Korean Medicine (동의생리병리학회지)

The Physiological Society of Korean Medicine and The Society of Pathology in Korean Medicine (대한동의생리학회·한의병리학회)
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Geumeunyoungji-tang Inhibits Serum IgE Level in Mouse Dermatitis Induced by 2,4-dinitrofluorobenzene

  • Phan, Manh Hung (Department of Oriental Pharmacy and Wonkwang Oriental Medicines Research Institude, College of Pharmacy, Wonkwang University) ;
  • Jeon, Yong Deok (Department of Oriental Pharmacy and Wonkwang Oriental Medicines Research Institude, College of Pharmacy, Wonkwang University) ;
  • Kim, Min Cheol (Department of Oriental Pharmacy and Wonkwang Oriental Medicines Research Institude, College of Pharmacy, Wonkwang University) ;
  • Kim, Su Jin (Department of Cosmeceutical Science, Daegu Hanny University) ;
  • Kim, Dae Seung (Department of Oriental Pharmacy and Wonkwang Oriental Medicines Research Institude, College of Pharmacy, Wonkwang University) ;
  • Kwon, Dong Yeul (Department of Oriental Pharmacy and Wonkwang Oriental Medicines Research Institude, College of Pharmacy, Wonkwang University) ;
  • Kim, Seong Hee (Department of Oriental Pharmacy and Wonkwang Oriental Medicines Research Institude, College of Pharmacy, Wonkwang University) ;
  • No, Seung Il (Department of Oriental Pharmacy and Wonkwang Oriental Medicines Research Institude, College of Pharmacy, Wonkwang University) ;
  • Kim, Hyun Jeong (Department of Oriental Pharmacy and Wonkwang Oriental Medicines Research Institude, College of Pharmacy, Wonkwang University) ;
  • Shin, Hyun Ji (Department of Oriental Pharmacy and Wonkwang Oriental Medicines Research Institude, College of Pharmacy, Wonkwang University) ;
  • Um, Jae Young (College of Oriental Medicine, Kyung Hee University) ;
  • Hong, Seung Heon (Department of Oriental Pharmacy and Wonkwang Oriental Medicines Research Institude, College of Pharmacy, Wonkwang University)
  • Received : 2014.01.17
  • Accepted : 2014.03.11
  • Published : 2014.04.25
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Abstract

Lonicerae Flos containing formulation, Geumeumyoungji-tang (GYT), is an herbal prescription prepared using 5 different herbal drugs, namely, Lonicerae Flos, Ganoderma, Lactucae Herba, Xanthii Fructus, and Smilacis Rhizoma. This study was focused on the investigation of the pharmacological effects of GYT on allergic reactions. As the first step of the study, GYT was administered BALB/c mice which were sensitized by 2,4-dinitrofluorobenzene (DNFB). As the result GYT ameliorated dermatitis provoked by DNFB. The serum IgE level of the DNFB sensitized-mouse was significantly decreased when GYT was administered. In order to confirm the moderating effect of this prescription on allergic reaction, GYT was pretreated to human mast cells (HMC-1) before they were stimulated by phorbol-12-myristate 13-acetate plus calcium ionophore A23187 (PMACI). GYT suppressed secretion of inflammatory cytokines, interleukin (IL)-6 and IL-8, from HMC-1. Additionally, pretreatment of GYT showed regulating effect on COX-2 expression. Collectively, these findings provide insights into the pharmacological actions of GYT as a potential agent for treatment of allergic dermatitis.

Keywords

References

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