Journal of Physiology & Pathology in Korean Medicine (동의생리병리학회지)

The Physiological Society of Korean Medicine and The Society of Pathology in Korean Medicine (대한동의생리학회·한의병리학회)
권호 표지

Effects of Flos Sophorae Ethanol Extract on NF-${\kappa}B$ Dependent MMP-9 Expression in Human Breast Cancer Cell

유방암세포에서 괴화 에탄올 추출물의 NF-${\kappa}B$ 의존적인 MMP-9 발현의 조절 규명을 위한 연구

  • Kim, Jeong Mi (Center for Metabolic Function Regulation, Wonkwang University School of Medicine) ;
  • Lee, Young Rae (Center for Metabolic Function Regulation, Wonkwang University School of Medicine) ;
  • Hwang, Jin Ki (Center for Metabolic Function Regulation, Wonkwang University School of Medicine) ;
  • Kim, Mi Seong (Center for Metabolic Function Regulation, Wonkwang University School of Medicine) ;
  • Kim, Ha Rim (Center for Metabolic Function Regulation, Wonkwang University School of Medicine) ;
  • Park, Yeon Ju (Center for Metabolic Function Regulation, Wonkwang University School of Medicine) ;
  • You, Yong Ouk (Department of Oral Biochemistry, and Institute of Biomaterials.Implant, School of Dentistry, Wonkwang University) ;
  • Kim, Seong Cheol (Department of Korean Physiology, School of Korean Medicine, Wonkwang University) ;
  • Ryu, Do Gon (Department of Korean Physiology, School of Korean Medicine, Wonkwang University) ;
  • Kwon, Kang Beom (Department of Korean Physiology, School of Korean Medicine, Wonkwang University)
  • 김정미 (원광대학교 대사질환 연구센터) ;
  • 이영래 (원광대학교 대사질환 연구센터) ;
  • 황진기 (원광대학교 대사질환 연구센터) ;
  • 김미성 (원광대학교 대사질환 연구센터) ;
  • 김하림 (원광대학교 대사질환 연구센터) ;
  • 박연주 (원광대학교 대사질환 연구센터) ;
  • 유용욱 (원광대학교 치과대학 생화학교실, 생체재료.매식 연구소) ;
  • 김성철 (원광대학교 한의과대학 한방생리학교실) ;
  • 류도곤 (원광대학교 한의과대학 한방생리학교실) ;
  • 권강범 (원광대학교 한의과대학 한방생리학교실)
  • Received : 2013.12.11
  • Accepted : 2014.02.11
  • Published : 2014.02.25
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Abstract

Flos Sophorae, the dried flower bud of Sophora japonica L, possesses anti-inflammatory properties, prevents and treats blood capillary and hypertension diseases and can also be used as a hemostat. However, the effect of Flos Sophorae on breast cancer invasion is unknown. Matrix metalloproteinase-9 (MMP-9), which degrades the extracellular matrix, is a major component in cancer cell invasion. In this study, we investigated the inhibitory effect of Flos Sophorae extract (FSE) on 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced Matrix metalloproteinase-9 (MMP-9) expression and cell invasion, as well as the molecular mechanisms involved in Michigan Cancer Foundation-7 (MCF-7) cells. FSE inhibited the TPA-induced transcriptional activation of nuclear factor-kappa B (NF-${\kappa}B$). These results indicate that FSE-mediated inhibition of TPA-induced MMP-9 expression and cell invasion involves the suppression of NF-${\kappa}B$ pathway in MCF-7 cells. Thus, FSE may have therapeutic potential for controlling breast cancer invasiveness.

Keywords

References

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