The Korean Journal of Physiology and Pharmacology

The Korean Society of Pharmacology (대한약리학회)
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Far-infrared radiation stimulates platelet-derived growth factor mediated skeletal muscle cell migration through extracellular matrix-integrin signaling

  • Lee, Donghee (Department of Physiology, Chung-Ang University College of Medicine) ;
  • Seo, Yelim (Department of Physiology, Chung-Ang University College of Medicine) ;
  • Kim, Young-Won (Department of Physiology, Chung-Ang University College of Medicine) ;
  • Kim, Seongtae (Department of Physiology, Chung-Ang University College of Medicine) ;
  • Bae, Hyemi (Department of Physiology, Chung-Ang University College of Medicine) ;
  • Choi, Jeongyoon (Department of Physiology, Chung-Ang University College of Medicine) ;
  • Lim, Inja (Department of Physiology, Chung-Ang University College of Medicine) ;
  • Bang, Hyoweon (Department of Physiology, Chung-Ang University College of Medicine) ;
  • Kim, Jung-Ha (Department of Family Medicine, Chung-Ang University Hospital, Chung-Ang University College of Medicine) ;
  • Ko, Jae-Hong (Department of Physiology, Chung-Ang University College of Medicine)
  • Received : 2018.12.29
  • Accepted : 2019.01.11
  • Published : 2019.03.01
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Abstract

Despite increased evidence of bio-activity following far-infrared (FIR) radiation, susceptibility of cell signaling to FIR radiation-induced homeostasis is poorly understood. To observe the effects of FIR radiation, FIR-radiated materials-coated fabric was put on experimental rats or applied to L6 cells, and microarray analysis, quantitative real-time polymerase chain reaction, and wound healing assays were performed. Microarray analysis revealed that messenger RNA expressions of rat muscle were stimulated by FIR radiation in a dose-dependent manner in amount of 10% and 30% materials-coated. In 30% group, 1,473 differentially expressed genes were identified (fold change [FC] > 1.5), and 218 genes were significantly regulated (FC > 1.5 and p < 0.05). Microarray analysis showed that extracellular matrix (ECM)-receptor interaction, focal adhesion, and cell migration-related pathways were significantly stimulated in rat muscle. ECM and platelet-derived growth factor (PDGF)-mediated cell migration-related genes were increased. And, results showed that the relative gene expression of actin beta was increased. FIR radiation also stimulated actin subunit and actin-related genes. We observed that wound healing was certainly promoted by FIR radiation over 48 h in L6 cells. Therefore, we suggest that FIR radiation can penetrate the body and stimulate PDGF-mediated cell migration through ECM-integrin signaling in rats.

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References

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