Journal of Physiology & Pathology in Korean Medicine (동의생리병리학회지)

The Physiological Society of Korean Medicine and The Society of Pathology in Korean Medicine (대한동의생리학회·한의병리학회)
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Studies on Anti-inflammatory Effects of Yangdan-tang Extracts

양단탕 추출물의 항염증 효과에 대한 연구

  • Choi, Su Ryeon (School of Cosmetic Science and Beauty Biotechnology, Semyung University) ;
  • Hwang, Hyung Seo (School of Cosmetic Science and Beauty Biotechnology, Semyung University) ;
  • Kim, Tae Yeon (College of Korean Medicine, Semyung University)
  • 최수련 (세명대학교 화장품뷰티생명공학부) ;
  • 황형서 (세명대학교 화장품뷰티생명공학부) ;
  • 김태연 (세명대학교 한의과대학)
  • Received : 2020.08.14
  • Accepted : 2020.10.06
  • Published : 2020.10.25
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Abstract

Yangdan-tang (YD) is recorded as a treatment to treat exterior-related fever illness in the Korean medicine. In this study, we examined the anti-inflammatory effects of YD, using YD water extract and lipopolysaccharide (LPS)-induced RAW 264.7 cells. First of all, we measured the amount of nitric oxide (NO) and prostaglandin E2 (PGE2), the products of inflammatory metabolism. Also, we measured enzymes such as inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2), as well as cytokines such as tumor necrosis factor alpha (TNF-α), interleukin 6 (IL-6), interleukin 1 alpha (IL-1α), and interleukin 1 beta (IL-1β). YD suppressed the production of NO and PGE2 in a dose dependent manner and reduced the amount of protein and the mRNA expression of iNOS and COX-2. Also, YD reduced the mRNA expression of TNF-α, IL-6, IL-1α and IL-1β. In conclusion, YD decreased production of LPS-induced inflammatory factor, which could be a clinical basic subject for inflammatory diseases.

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References

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