DOI QR코드

DOI QR Code

Serum Vitamin E levels and Allergic Rhinitis : Analysis of the KNHANES VII-3

혈중 비타민 E 수준과 알레르기 비염 : 국민건강영양조사 제7기 3차년도 자료 분석

  • Received : 2020.09.21
  • Accepted : 2020.10.20
  • Published : 2020.10.31

Abstract

The purpose of this study was to investigate the relationship between serum vitamin E levels and the risk of allergic rhinitis among Koreans. This study is a secondary data analysis using big data from the seventh Korea National Health and Nutrition Examination Survey (KNHANES VII-3), which was conducted in 2018. Complex-sample descriptive statistics, t-test, ANOVA and odds ratio were used for data analysis in SPSS 25. The average serum vitamin E level among Koreans aged above 10 was 12.60 mg/L, and 15.9% had been diagnosed with of allergic rhinitis by a doctor. Lower serum vitamin E levels were significantly associated with the prevalence of allergic rhinitis (β=-0.05, p=.013). Therefore, efforts to prevent and manage allergic rhinitis among Koreans should incorporate regular monitoring of vitamin E level and ongoing research into antioxidants.

본 연구의 목적은 한국인의 혈중 비타민 E 수준과 알레르기 비염의 위험도를 파악하기 위함이다. 연구방법은 국민건강영양조사 제7기 3차년도(2018) 빅데이터를 활용한 이차분석 연구이다. 자료분석은 SPSS 25 프로그램을 사용하여 복합표본 빈도와 백분율, 복합표본 교차분석, t-test, ANOVA 그리고 Odds ratio를 실시하였다. 연구결과, 우리나라 10세 이상 혈중 비타민 E 수준는 평균 12.60mg/L이었고, 의사로부터 알레르기 비염을 진단받은 사람은 15.9%였다. 연구 대상자의 혈중 비타민 E 수준이 낮을수록 알레르기 비염 유병은 유의하게 높은 것으로 나타났다(β=-0.05, p=.013). 따라서 한국인의 알레르기 비염 예방 및 관리를 위해서는 혈중 비타민 E 모니터링 및 비타민 E 를 포함한 항산화제에 대한 연구를 지속적으로 해야 할 것이다.

Keywords

References

  1. World Health Organization. (2020). Coronavirus disease (COVID-19) pandemic. WHO(Online). https://www.who.int/emergencies/diseases/novel-coronavirus-2019?gclid=CjwKCAjw-5v7BRAmEiwAJ3DpuOYpH1Ikb8VDx-xEFs_eISr9KDbDEI9sM5n0xCb-F_GnjYvoMD-_hhoCIU4QAvD_BwE
  2. Y. J. Jo. (2020. 9. 8.). The stress of not having to travel abroad can be relieved by shopping abroad. News of The Financial News. The Financial News(Online). https://www.fnnews.com/news/202009081742434504
  3. B. K. Kim. (2020. 9. 15.). After COVID-19, increasing interest in immunity products. News of Yonhapnews. Yonhapnews(Online). https://www.yna.co.kr/view/AKR20200914141500030?input=1195m
  4. N. S Jang, Y. J. Lee, K. H. Kang, W. K. Kim, E. J. Jeong & Y. K. Park. (2004). New paradigm of dietary reference intakes (DRIs) : DRIs in USA and Canada - vitamin C, E and selenium. Journal of Nutrition and Health, 37(7), 588-595.
  5. G. F. M. Ball. (2004). Vitamins: their role in the human body. Oxford: Blackwell Publishing.
  6. G. Y. Lee & S. N. Han. (2018). The role of vitamin E in immunity. Nutrients, 10(11), 1-18. DOI : 10.3390/nu10111614
  7. S. H. Park, S. N. Kim, S. H. Lee, J. S. Choe & Y. M. Choi. (2018). Development of 9th revision Korean food composition table and its major changes. Korean Journal of Community Nutrition, 23(4), 352-365. DOI : 10.5720/kjcn.2018.23.4.352
  8. Ministry of Health and Welfare and the Korean Nutrition Society. (2016). Dietary reference intakes for Koreans 2015. KNS(Online). http://www.kns.or.kr/FileRoom/FileRoom_view.as p?idx=79&BoardID=Kdr
  9. P. Li, H. Zhang, J. Chen, Y. Shi, J. Cai, J. Yang & Y. Wu. (2014). Association between dietary antioxidant vitamins intake/blood level and risk of gastric cancer. International Journal of Cancer, 135(6), 1444-1453. DOI : 10.1002/ijc.28777
  10. Mayo Clinic. (2020). Vitamin E, serum. Mayo Clinic(Online). https://www.mayocliniclabs.com/test-catalog/Clinical+and+Interpretive/42358
  11. G. La Fata, P. Weber & M. H. Mohajeri. (2014). Effects of vitamin E on cognitive performance during ageing and in Alzheimer's disease. Nutrients, 6(12), 5453-5472. DOI : 10.3390/nu6125453
  12. L. Guo, H. Zhu, C. Lin, J. Che, X. Tian, S. Han, H. Zhao, Y. Zhu & D. Mao. (2015). Associations between antioxidant vitamins and the risk of invasive cervical cancer in Chinese women: a case-control study. Scientific Reports, 5(1), 1-10. DOI : 10.1038/srep13607
  13. J. Gaziano. (2005). Vitamin E and cardiovascular disease: observational studies. Aannals of the New York Academy of Sciences, 1031(1), 280-291. DOI : 10.1196/annals.1331.028
  14. I. Romieu, J. J. Sienra-Monge, M. Ramirez-Aguilar, M. M. Tellez-Rojo, H. Moreno-Macias, N. I. Reyes-Ruiz, B. E. del Río-Navarro, M. X. Ruiz-Navarro, G. Hatch, R. Slade & M. Hernandez-Avila. (2002). Antioxidant supplementation and lung functions among children with asthma exposed to high levels of air pollutants. American Journal of Respiratory and Critical Care Medicine, 166(5), 703-709. DOI : 10.1164/rccm.2112074
  15. M. Celik, A. Tuncer, O. U. Soyer, C. Sackesen, H. Tanju-Besler & O. Kalayci. (2012). Oxidative stress in the airways of children with asthma and allergic rhinitis. Pediatric Allergy and Immunology, 23(6), 556-561. DOI : 10.1111/j.1399-3038.2012.01294.x
  16. Statistics Korea. (2020). Korea health statistics 2018: Korea National Health and Nutrition Examination Survey (KNHANES VII-3). KOS(Online). https://www.index.go.kr/potal/main/EachDtlPage Detail.do?idx_cd=1438
  17. N. Hijazi, B. Abalkhail & A. Seaton. (2000). Diet and childhood asthma in a society in transition: a study in urban and rural Saudi Arabia. Thorax, 55(9), 775-779. DOI : 10.1136/thorax.55.9.775
  18. E. Shahar, G. Hassoun & S. Pollack. (2004). Effect of vitamin E supplementation on the regular treatment of seasonal allergic rhinitis. Annals of Allergy, Asthma & Immunology, 92(6), 654-658. DOI : 10.1016/S1081-1206(10)61432-9
  19. J. M. Cook-Mills, T. Gebretsadik, H. Abdala-Valencia, J. Green, E. K. Larkin, W. D. Dupont, X. O. Shu, M. Gross, C. Bai, Y. T. Gao, T. J. Hartman, C. Rosas-Salazar & T. Hartert. (2016). Interaction of vitamin E isoforms on asthma and allergic airway disease. Thorax, 71(10), 954-956. DOI : 10.1136/thoraxjnl-2016-208494
  20. J. M. Cook-Mills & P. C. Avila. (2014). Vitamin E and D regulation of allergic asthma immunopathogenesis. International Immunopharmacology, 23(1), 364-372. DOI : 10.1016/j.intimp.2014.08.007
  21. H. Wu, C. Zhang, Y. Wang & Y. Li. (2018). Does vitamin E prevent asthma or wheeze in children: a systematic review and meta-analysis. Paediatric Respiratory Reviews, 27, 60-68. DOI : 10.1016/j.prrv.2017.08.002
  22. Korea Centers for Disease Control and Prevention. (2018). The seventh Korea National Health and Nutrition Examination Survey (KNHANES VII-3). KCDC(Online). https://knhanes.cdc.go.kr/knhanes/sub03/sub03_06_02.do
  23. S. E Ahn, S. Y. Jun, S. A. Kim, K. H. Ha & H. J. Joung. (2017). Current status and trends in estimated intakes and major food groups of vitamin E among Korean adults: using the 1-6th Korea National Health and Nutrition Examination Survey. Journal of Nutrition and Health, 50(5), 483-495. DOI : 10.4163/jnh.2017.50.5.483
  24. D. W. Ham, S. A. Kim, S. Y. Jun, M. S. Kang & H. J. Joung. (2018). Association between antioxidant vitamin intake and obesity among Korean women : using the Korea National Health and Nutrition Examination Survey 2007-2016. Journal of Nutrition and Health, 51(5), 400-413. DOI : 10.4163/jnh.2018.51.5.400
  25. N. S. Jang, Y. J. Lee, K. H. Kang, W. K. Kim, E. J. Jeong & Y. K. Park. (2004). New paradigm of dietary reference intakes (DRIs) : DRIs in USA and Canada - vitamin C, E and selenium. Journal of Nutrition and Health, 37(7), 588-595.
  26. S. Wang, Y. F. Wang, C. Pan & J. Sun. (2020). Serum level and clinical significance of vitamin E in children with allergic rhinitis. BMC Pediatrics, 20(362), 1-8. DOI : 10.1186/s12887-020-02248-w
  27. K. Saad, A. Abdelmoghny, M. D. Aboul-Khair, Y. F. Abdel-Raheem, E. F. Gad, A. E. S. Hammour, B. Hawary, A. M. Zahran, M. A. Alblihed & A. Elhoufey. (2020). Vitamin D status in Egyptian children with allergic rhinitis. Ear, Nose & Throat Journal, 99(8), 508-512. DOI : 10.1177/0145561319850814
  28. A. Fogarty, S. Lewis, S. Weiss & J. Britton. (2000). Dietary vitamin E, IgE concentrations, and atopy. Lancet, 356(9241), 1573-1574. DOI : 10.1016/s0140-6736(00)03132-9
  29. J. H. Seo, S. O. Kwon, S. Y. Lee, H. Y. Kim, J. W. Kwon, B. J. Kim, J. Yu, H. B. Kim, W. K. Kim, G. C. Jang, D. J. Song, J. Y. Shim, S. Y. Oh & S. J. Hong. (2013). Association of antioxidants with allergic rhinitis in children from Seoul. Allergy, Asthma & Immunology Research, 5(2), 81-87. DOI : 10.4168/aair.2013.5.2.81
  30. B. B. M. Velazquez, K. Jauregui-Renaud, A. C. B. Arias, J. C. Ayala, M. D. M. Martinez, R. C. Navarrete, I. S. V. Rosalia, M. R. C. Salazar, H. A. C. Serrano, A. O. Mondragon & R. L. Perez. (2006). Vitamin E effects on nasal symptoms and serum specific IgE levels in patients with perennial allergic rhinitis. Annals of Allergy, Asthma & Immunology, 96(1), 45-50. DOI : 10.1016/S1081-1206(10)61039-3