동의생리병리학회지 (Journal of Physiology & Pathology in Korean Medicine)

  • 제36권3호
  • /
  • Pages.94-99
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  • 2022
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  • 1738-7698(pISSN)
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  • 2288-2529(eISSN)
대한동의생리학회·한의병리학회 ( The Physiological Society of Korean Medicine and The Society of Pathology in Korean Medicine)
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다주파수 생체임피던스 저항을 이용한 당뇨병 환자의 허증 변증 예측

Prediction of Deficiency Pattern in Diabetic Patients Using Multi-frequency Bioimpedance Resistance

  • 김가혜 (한국한의학연구원 디지털임상연구부) ;
  • 김슬기 (한국한의학연구원 디지털임상연구부) ;
  • 차지윤 (한국한의학연구원 디지털임상연구부) ;
  • 유호룡 (대전대학교 한방내과) ;
  • 김재욱 (한국한의학연구원 디지털임상연구부)
  • Kim, Kahye (Digital Health Research Division Korea Institute of Oriental Medicine) ;
  • Kim, Seul Gee (Digital Health Research Division Korea Institute of Oriental Medicine) ;
  • Cha, Jiyun (Digital Health Research Division Korea Institute of Oriental Medicine) ;
  • Yoo, Ho-Ryong (Internal Medicine of Cardiovascular, Daejeon University) ;
  • Kim, Jaeuk U. (Digital Health Research Division Korea Institute of Oriental Medicine)
  • 투고 : 2022.03.31
  • 심사 : 2022.06.22
  • 발행 : 2022.06.25
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초록

The discovery of biomarkers related to pattern identification (PI), the core diagnostic theory of Korean medicine (KM), is one of the methods that can provide objective and reliable evidence by applying PI to clinical practice. In this study, 40 diabetic patients and 41 healthy control subjects recruited from the Korean medicine clinic were examined to determine the human electrical response related to the deficiency pattern, a representative pattern of diabetes. Qi-Blood-Yin-Yang deficiency pattern scores, which are representative deficiency patterns for diabetes mellitus, were obtained through a questionnaire with verified reliability and validity, and the human electrical response was measured non-invasively using a bioimpedance meter. In ANCOVA analysis using gender as a covariate, the 5 kHz frequency resistance and 5-250 kHz frequency reactance were significantly lower in the diabetic group than in non-diabetic control group. In addition, the multiple regression analysis showed a positive correlation (R2=0.11~0.19) between the Yang deficiency pattern score and resistance value for the diabetic group; the correlation was higher at higher frequencies of 50kHz (R2=0.18) and 250kHz (R2=0.19) compared to 5kHz(R2=0.11). In contrast, there was no such significant association in the control group. It implies that bioimpedance resistance measured at finite frequencies may be useful in predicting Yang deficiency, which is closely related to diabetic complications by reflecting the decrease in body water content and metabolism. In the future, large-scale planned clinical studies will be needed to identify biomarkers associated with different types of PI in diabetes.

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과제정보

이 논문은 한국한의학연구원 주요사업(KSN2022130)에 의하여 연구되었음.

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