대한약리학회지 (The Korean Journal of Pharmacology)

대한약리학회 (The Korean Society of Pharmacology)
권호 표지

2, 2'Methylene bis (3,4,6 trichlorophenoxy Acetic Acid) 및 Sodium Cholate의 간흡충(肝吸?) 산소소비(酸素消費) 및 살충작용(殺?作用)

Effects of 2, 2'-Methylene bis-(3,4,6-Trichlorophenoxy Acetic acid) 'MTPA' and Hexachlorophene with or without Sodium Cholate on the Oxygen Consumption in Clonorchis Sinensis

  • 김화웅 (경북대학교 의과대학 약리학교실) ;
  • 김중영 (경북대학교 의과대학 약리학교실) ;
  • 윤병오 (경북대학교 의과대학 약리학교실) ;
  • 하영호 (경북대학교 의과대학 약리학교실)
  • Kim, Hwa-Woong (Department of Pharmacology, Kyungpook National University, School of Medicine) ;
  • Kim, Choong-Young (Department of Pharmacology, Kyungpook National University, School of Medicine) ;
  • Yun, Byung-Oh (Department of Pharmacology, Kyungpook National University, School of Medicine) ;
  • Ha, Young-Ho (Department of Pharmacology, Kyungpook National University, School of Medicine)
  • 발행 : 1969.06.30
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초록

The inhibitory action of oxygen consumption and parasiticidal action of hexachlorophene or MTPA combined with or without sodium cholate in Clonorchis sinensis (C.S) have been observed. The results were obtained as follows. 1. In low concentration of MTPA or Hexachlorophene, they inhibited the oxygen consumption of C.S and in high concentration, inhibition of oxygen consumption and parasiticidal action was more remarkable. 2. The oxygen consumption was inhibited also in the concentration of $10^{-2}$ and $2{\times}10^{-3}g/ml$ of sodium cholate. 3. In the presence of sodium cholate, oxygen consumption of C.S was more remarkably inhibited by MTPA or Hexachlorophene than the absence of sodium cholate. 4. From those results, it may be considered that sodium cholate combined with MTPA or Hexachlorophene produced potentiation in its action.

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