Study of Dansameum on the Pharmacological Effect

단삼음(丹蔘飮)의 약리효능에 대한 연구

  • Received : 2010.09.07
  • Accepted : 2010.10.08
  • Published : 2010.10.25

Abstract

The purpose of this research was to investigate the pharmacological effects of Dansameum (DSE) water extract which is composed with Salviae Radix, Santali Lignum and Amomi Semen. DSE was administered orally at the concentartion of 100 and 500 mg/kg. DSE decreased the writhing syndrome induced by acetic acid and the permeability of evans blue into peritoneal cavity. Also, DSE inhibited the production of nitric oxide from murine macrophages. Futhermore, DSE protected the liver injury induced by galactosamine in vitro system and $CCl_4$ in vivo system. These results suggest that DSE has a diverse effects such as analgesic action, inflammatory action and liver protective action.

Keywords

References

  1. 陳修園. 醫學全書.時方歌括. 北京, 中國中醫藥出版社, p 956, 2006.
  2. 江克明 外. 簡明方劑辭典. 上海, 上海科學技術出版社, p 221, 1989.
  3. Jae Soon Eun, Jong Pil Lim, Yi Kyu Park, Dong Seong Choi and Moon Seng Ahn. Hepatoprotective Activity of Salviae miltiorrhizae Radix Extract, 22(2):95-100, 1991.
  4. Park, E.J., Zhao, Y.Z., Kim, Y.C., Sohn, D.H. Preventive effects of a purified extract isolated from Salvia miltiorrhiza enriched with tanshinone I, tanshinone IIA and cryptotanshinone on hepatocyte injury in vitro and in vivo. Food Chem. Toxicol., 47(11):2742-2748, 2009. https://doi.org/10.1016/j.fct.2009.08.007
  5. Chor, J.S., Yu, J., Chan, K.K., Go, Y.Y., Sung, J.J. Stephania tetrandra prevents and regresses liver fibrosis induced by carbon tetrachloride in rats. J. Gastroenterol. Hepatol., 24(5):853-859, 2009. https://doi.org/10.1111/j.1440-1746.2008.05720.x
  6. 손윤희, 조현정, 장현욱, 손건호, 남경수. 단삼 분획추출물의 암예방 효과, Journal of Life Science, 16(3):369-374, 2006. https://doi.org/10.5352/JLS.2006.16.3.369
  7. 최선미, 최승훈, 안규석. Study on Antitumor and Apoptosis - Inducing Effects of Salviae miltiorrhizae Radix, 14(2):22-47, 2000.
  8. Lee, W.Y., Cheung, C.C., Liu, K.W., Fung, K.P., Wong, J., Lai, P.B., Yeung, J.H. Cytotoxic effects of tanshinones from Salvia miltiorrhiza on doxorubicin-resistant human liver cancer cells. J. Nat. Prod., 73(5):854-859, 2010. https://doi.org/10.1021/np900792p
  9. Cha Jae-Young, Ha Se-Eun, Sim Seon-Mi, Park Jong-Kun, Chung Yeon-Ok, Kim Hyun-Joong, Park Nou-Bog. Antimicrobial Effects of Ethanol Extracts of Korea Endemic Herb Plants, Journal of Life Science 18(2):228-233, 2008. https://doi.org/10.5352/JLS.2008.18.2.228
  10. 김창민 外. 完譯 中藥大辭典, 서울, 도서출판 정담, p 866, 1999.
  11. 김창민 外. 完譯 中藥大辭典 5권. 서울, 도서출판 정담, p 1983, 1999.
  12. Whittle, B.A. The use of changes in capillary permeability in mice to distinguish between narcotic and nonnarcotic analgesics. Brit. J. Pharmacol. 22: 246-253, 1964.
  13. Shimomura, K., Fukushima, T. A new method for the rapid determination of azovan blue leaked into the skin. J. Pharm. Pharmacol. 24(10):837-838, 1972. https://doi.org/10.1111/j.2042-7158.1972.tb08899.x
  14. Rockett, K.A., Awburn, M.M., Cowden, W.B. and Clark, I.A. Killing of Plasmodium faciparum in vitro by nitric oxide derivatives. Infec. Immunity, 59(9):3280, 1991.
  15. Park, E.J., Zhao, Y.Z., Na, M., Bae, K., Kim, Y.H., Lee, B.H., Sohn, D.H. Protective effects of honokiol and magnolol on tertiary butyl hydroperoxide- or D-galactosamine-induced toxicity in rat primary hepatocytes. Planta Med. 69(1):33-37, 2003. https://doi.org/10.1055/s-2003-37027
  16. Mosmann, T. Rapid colorimetric assay for cellular growth and survival: application to proliferation and cytotoxic assays. J. Immunol. methods. 65: 55, 1983.
  17. Kotnic, V. and Fleischmann, W.R.Jr. A simple and rapid method to determine hematopoietic growth factor activity. J. Immunol. methods. 129: 23, 1990. https://doi.org/10.1016/0022-1759(90)90416-S
  18. Iga, T., Sugiyama, Y., Yokota, M., Tomono, Y., Awazu, S., Hanano, M. Pharmacokinetic aspects of sulfobromophthalein transport in chronically carbon tetrachloride-intoxicated rats. Biochem. Pharmacol., 26(20):1867-1875, 1977. https://doi.org/10.1016/0006-2952(77)90160-5
  19. Reitman, S., Frankel, S. A colorimetric method for the determination of serum glutamic oxalacetic and glutamic pyruvic transaminases. Am. J. Clin. Pathol., 28(1):56-63, 1957. https://doi.org/10.1093/ajcp/28.1.56
  20. Matsushita, K., Morrell, C.N., Cambien, B., Yang, S.X., Yamakuchi, M., Bao, C., Hara, M.R., Quick, R.A., Cao, W., O'Rourke, B., Lowenstein, J.M., Pevsner, J., Wagner, D.D., Lowenstein, C.J. Nitric Oxide Regulates Exocytosis by S-Nitrosylation of N-ethylmaleimide-Sensitive Factor. Cell, 115(2):139-150, 2003. https://doi.org/10.1016/S0092-8674(03)00803-1
  21. Clawson, G.A. Mechanisms of carbon tetrachloride hepatotoxicity. Pathol. Immunopathol. Res., 8(2):104-112, 1989. https://doi.org/10.1159/000157141
  22. Ding, H., Huang, J.A., Tong, J., Yu, X., Yu, J.P. Influence of Kupffer cells on hepatic signal transduction as demonstrated by second messengers and nuclear transcription factors. World J. Gastroenterol., 9(11):2519-2522, 2003. https://doi.org/10.3748/wjg.v9.i11.2519
  23. Cherkasov, V.S., Nemchenko, N.S. [Determination of the activity of blood serum alanine- and aspartate aminotransferases (ALT, AST) in various forms of hearing disorders]. Zh Ushn Nos Gorl Bolezn. (2):23-26, 1978.