Journal of Physiology & Pathology in Korean Medicine (동의생리병리학회지)

The Physiological Society of Korean Medicine and The Society of Pathology in Korean Medicine (대한동의생리학회·한의병리학회)
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Apoptotic Effects of Curcumin on the Epstein-Barr Virus-Transformed Human B Lymphoma Cells Activated by PWM

Curcumin이 PWM에 의해 활성화된 Epstein-Barr 바이러스 변형 사람 B 림프종 세포의 사멸에 미치는 효과

  • Ryu, Sang-Chae (Department of Third Medicine, Professional Graduate School of Oriental Medicine, Wonkwang University) ;
  • Lee, Jang-Suk (Department of Preventive Medicine, College of Oriental Medicine, Wonkwang University) ;
  • Chong, Myong-Soo (Department of Preventive Medicine, College of Oriental Medicine, Wonkwang University) ;
  • Lee, Ki-Nam (Department of Preventive Medicine, College of Oriental Medicine, Wonkwang University)
  • 유상채 (원광대학교 한의학전문대학원 제3의학과) ;
  • 이장석 (원광대학교 한의과대학 예방의학교실) ;
  • 정명수 (원광대학교 한의과대학 예방의학교실) ;
  • 이기남 (원광대학교 한의과대학 예방의학교실)
  • Received : 2012.03.20
  • Accepted : 2012.04.26
  • Published : 2012.06.25
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Abstract

The results of this study intended to clarify the apoptotic effects of curcumin on Epstein-Barr virus transformed human B lymphoma (EBV-B) cells are summarized as follows: It was found that curcumin induced endoplasmic reticulum(ER) stress as well as apoptotic cell death in EBV-B cells, although the magnitude of action was insignificant. When EBV-B cells activated by pokeweed mitogen (PWM) were treated with the same concentrations of curcumin, it was found that higher ER stress (GRP78, P-PERK, XBP-1, ATF6, and CHOP expressed) increased unfold protein response (UPR) and thus, apoptosis attributed to ER stress, compared to non-activated EBV-B cells In conclusion, it is expected that curcumin will play an important role for leukemia treatment.

Keywords

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